Cephalosporins

Question 1

Stability, metabolism, adverse effects, drug interactions, protein binding, half life

Answer 1

R2

Question 2

Oral agents have good or bad absorption?

Answer 2

Good

Question 3

Oral cephalosporins available as __________ and _________ compounds

Answer 3

prodrug esters

nonesterified compounds

Question 4

Prodrug esters hydrolyzed in ___________ to active drug

Food enhances or decrease absorption

Answer 4

intestines

enhances

Question 5

Cefuroxime (2nd gen.) and cefpodoxime proxetil (3rd gen) are

Answer 5

Prodrug esters

Question 6

Binds to _________ and inhibits crosslinking of peptidoglycan strands

Answer 6

PBPs

Question 7

Well or poorly distributed to body tissues and fluids?

Answer 7

Well

Question 8

CSF penetration?

Answer 8

Yes, especially with inflamed meninges

Question 9

Good for meningitis

High or low dosage?

Answer 9

3rd generation
Ceftriaxone
High (4X normal)

Question 10

All ___________ excretion except 2 agents

Answer 10

Renal

Question 11

Ceftriaxone and cefoperazone have ________ elimination

Answer 11

hepatic

Question 12

_____________ associated with n-methylthiotetrazole side chain (NMTT)

Answer 12

bleeding

Question 13

Cefamandole and cefoperazone disturb _________ factors

Answer 13

vitamin K clotting dependent

Question 14

Causes disulfiram-like intolerance with _______________ when agents have _________

Answer 14

alcohol

NMTT side chain

Question 15

Causes serum sickness in children

Answer 15

cefaclor (2nd gen)

Question 16

Prolongs excretion in cephalosporins that have tubular secretion

Answer 16

Probenecid

Question 17

Use for community acquired pneumonia

Answer 17

3rd generations

Question 18

Use ceftaz and cefepime for

Answer 18

nosocomial pneumonia

Question 19

Use ceftriazone for

Answer 19

meningitis with higher dosage

Question 20

Use for simple cellulitis skin infections with staph and strep

Answer 20

1st generation

Question 21

Use for complicated skin infections or diabetic patients

Answer 21

3rd/4th generations with cephamycins

Question 22

Used for surgical prophylaxis

Answer 22

Cefazolin

Question 23

Use ceftazidime/van or cefepime/van for

Answer 23

febrile neutropenia

Question 24

Spectrum activity, PBP affinity, Beta-lactamase susceptibility

Answer 24

R1