Sulfonamides

Question 1

_____________ cofactor in synthesis of thymidine, purines, DNA

Answer 1

Tetrahydrofolic acid

Question 2

Bacteria permeable or impermeable to folic acid?

Answer 2

impermeable

Question 3

Bacteria must synthesis folic acid from _______

Answer 3

PABA

Question 4

Sulfonamides compete with PABA for __________

Answer 4

enzyme dihydropteroate synthetase

Question 5

Sulfonamides have _________ affinity for dihydropteroate synthetase

Answer 5

increased (more than PABA)

Question 6

Static or cidal?

Answer 6

Static

Question 7

Host cells not affected because they require __________ folic acid

Answer 7

preformed

Question 8

Dihydrofolate reducatase inhibited by

Answer 8

trimethoprim

Question 9

Excretion?

Answer 9

Renally

Question 10

Can cause morbilliform rash, steven johnson syndrome, erythema multiforme, and photosensitivity rash

Answer 10

sulfonamides

Question 11

Can cause _________ with less soluble compounds like sulfadiazine and sulfathiazole

Answer 11

crystalluria

Question 12

Administer with or without fluids?

Answer 12

With

Question 13

Can cause _______ when given in last months of pregnancy because it competes for _________ binding sites on plasma albumin

Causes increased or decreased fetal blood levels of unconjugated bilirubin?

Answer 13

Kernicterus
bilirubin
increased

Question 14

__________ can have structural change in dihydropteroate synthetase

Answer 14

E. coli

Question 15

Neisseria and staph overproduce _______

Answer 15

PABA

Question 16

Bacteria require ________ derivative of folic acid

Answer 16

Tetrahydrofolic acid