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Pharm > Aminoglycosides > Flashcards

Aminoglycosides Flashcards

1
Q

Binds to outer membrane of cell resulting in LPS rearrangement. Uptake is dependent upon energy from electrochemical gradient of bacterial cell. Trapped inside once across cytoplasm

A

Aminoglycoside

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2
Q

Binds to 30s and 50s leading to decreased protein synthesis and misreading of mRNA

High intracellular concs

A

Aminoglycoside

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3
Q

Batericidal or static?
Concentration or time dependent killing?
PAE or no PAE?

A

Cidal
Conc. dependent killing
PAE

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4
Q

Well absorbed or poorly from GI tract?

A

Poorly - aminoglycoside

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5
Q

Distributed freely or unfreely into vascular space?
Conc. in lungs are ________ of those in serum
Distribution to CSF _______ with inflammation

A

Freely
25-50%
20%

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6
Q

Excretion?

Low or high urinary conc?

A

Renal

High

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7
Q

Elderly (Vd and Ke)?

A

Decreased

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8
Q

Critically ill (Vd and ke)?

A

Change in Vd

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9
Q

Renal disease (Vd and Ke)

A

Decreased Ke

Change in Vd

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10
Q

Cachexia/Malnourished (Vd and ?)

A

Decreased Vd and creatinine production

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11
Q

Amputated limbs (Vd and Ke)?

A

Decreased Vd

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12
Q

Aminoglycosidic aminocyclitols

6 membered aminocyclitol ring (amino and non-amino containing sugars attach to ring by glycosidic linkages)

A

Aminoglycosides

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13
Q

Desired peak? Trough?

A

4-12 or 20-30

Less than 2

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14
Q

Too high peak can cause

Too high trough can cause

A

Otoxicity (8th CN)

Nephrotoxicity

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15
Q

Only aminoglycoside available orally? Rest are IV and IM

A

Neomycin

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16
Q

Substantial variations existing in concentrations achieved compared to what was predicted?

A

Nomogram

17
Q

7mg/kg for first dose then assess levels 6-14 after dose

A

Hartford nomogram

18
Q

___________ doses may be equally as effective as smaller multiple doses with __________ toxicity. Relies on PAE

A

Large daily

Less

19
Q

Narrow or broad therapeutic index?

A

Narrow

Pharm (14 decks)

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