Trimethoprim Flashcards
1
Q
________ more active against bacterial dihydrofolate reductase than human enzyme
A
50,000X
2
Q
Static or cidal?
A
Both depending on growth conditions
3
Q
Excretion?
A
Renally
4
Q
Can cause rash and ________
A
pruritis
5
Q
Caution in patients with __________ deficiency
Examples of patients
A
Folate
alcoholics, pregnant, debilitated, malabsorptive
6
Q
Non-sulfonamide pyrimidine analog
Inhibits dihydrofolate reductase which prevents formation of tetrahydrofolic acid
A
Trimethoprim
7
Q
Trimethoprim and sulfamethoxazole combined are
A
bactrim
8
Q
Bactrim used to ________ emergence of ________
A
reduce
resistance
9
Q
Bactrim potentiates anticoagulant effects of _________
Increases free _______ by displacing it from binding sites
A
Warfarin
Methotrexate
