Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Pharm > Macrolides > Flashcards

Macrolides Flashcards

1
Q

6-methoxy-erythromycin

A

Clarithomycin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Nitrogen group added to 14-member macrolide ring

A

Azithromycin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Reversibly binds to 50s. Decreases protein synthesis

A

Macrolides

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Bacteriocidal or static?

A

Static

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Erythomycins can be inactivated by bacteria by ___________

A

enzymatic degradation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Erythromycin base. Stearate and ethylsuccinate. Emycin estolate

A

Erythomycin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Rapidly inactivated by gastric acid (enteric and film coated forms __________ this inactivation)

A

Erythromycin base

Decrease

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Absorbed better in fasting state, empty stomach

A

Base, stearate, and ethylsuccinate

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Not affected by food

A

Emycin estolate

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Macrolides distribute in tissues ___________ than in blood

A

Longer

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Very high concentrations in ____________ and __________ compared to extracellular fluids

A

Alveolar macrophages

Leukocytes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Azithromycin tissue conc. ____________ those in serum

A

10-100X

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Erthromycin excretion?

A

Biliary mainly.

Small % in urine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Large portion of erthromycin _____ in liver by _________

A

inactivated

demethylation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Clarithomycin ___________ in liver by ____________ and _____________

A

metabolized
oxidation
hydrolysis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Clarithomycin

___________ of drug excreted in urine unchanged

A

20-30%

17
Q

Azithromycin
__________ metabolized

Excretion?

A

Small

Biliary

18
Q

Azithromycin half life?

Why helpful in 5 day regimen?

A

68 hrs

Slow release from tissues

19
Q

Avoid __________ form of __________ in pregnancy

A

estolate

erythromycin

20
Q

Side effects are headache, dizziness, allergic rxs

A

Clarithomycin

Azithromycin

21
Q

Form inactive complexes with P-450 enzymes.

Decreased metabolism of warfarin, theophlline, cyclosporine, carbamazepine

A

Erythromycin

Clarithomycin

22
Q

Does not inactive P-450 enzymes

A

Azithromycin

23
Q

Use ______________ for community acquired pneumonia

A

Clarithromycin and azithromycin

24
Q

Include clarithomycin, azithromycin, and erythromycin

A

Macrolides

Pharm (14 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions