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Pharm > Carbapenems > Flashcards

Carbapenems Flashcards

1
Q

Methyl group at C1 (no renal degradation)

C2 substitution dimethylcarbamylpyrrolidinethio side chain (increased gram - activity)

A

meropenem

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2
Q

Binds to ______ causing (cidal or static effect)?

A

PBP

Cidal

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3
Q

Has longest half life

A

Ertapenem (allows 1X daily)

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4
Q

Carbacephem beta-lactam agent. Sulfur replaced by carbone

A

Imipenem

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5
Q

Extensive renal metabolism by brush border enzyme dehydropeptidase-1. Cilastatin added to prevent renal metabolism

A

Imipenem

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6
Q

Commonly causes seizures

A

Imipenem

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7
Q

Does not cover enterococcus

A

Ertapenem

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8
Q

Monobactam antibiotic

A

Aztreonam

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9
Q

Aztreonam common or not common to have cross sensitivity with penicillin?

A

Not common

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10
Q

Gram - coverage only for?

A

Aztreonam

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Pharm (14 decks)

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