Chloramphenicol

Question 1

Reversibly binds 50s subunit

Answer 1

Chloramphenicol

Question 2

Must be __________ in ___________ for active chloramphenicol

Answer 2

hydrolyzed

intestines

Question 3

__________ form has incomplete hydrolysis

IV or oral?

Answer 3

IV

Question 4

Good or bad CSF conc?

Answer 4

Excellent

30-50% without inflammed meninges

Question 5

Metabolism via _________ in ____________

Answer 5

Glucuronidation

Liver

Question 6

Causes reversible bone marrow depression due to directly inhibiting ___________

Answer 6

mitochondrial protein synthesis

Question 7

Can cause __________ weeks to months after completion of therapy

Answer 7

Idiosyncratic aplastic anemia

Question 8

Can cause _____________ syndrome

Answer 8

Gray baby

Question 9

Abdominal distention, vomiting, cyanosis, circulatory collapse.

Caused by inhibition of mitochodrial protein synthesis

Answer 9

Gray baby syndrome

Question 10

Newborns lack effective _________ that degrades and detoxifies system of chloramphenicol

Answer 10

glucuronic acid conjugation

Question 11

Gray baby syndrome w/ conc higher than _______

Answer 11

50mcg/ml

Question 12

Good coverage. Bad side effects.

Answer 12

Chloramphenicol