Others

Question 1

Inhibits chain formation resulting in early termination

Answer 1

Quinupristin

Question 2

Inhibits peptide elongation by interfering with peptidyl transferase

Answer 2

Dalfopristin

Question 3

Oxazolidinone class. Binds 23s of 50s subunit. IV and PO are both 100% bioavailable

Answer 3

Linezolid

Question 4

Has interaction w/ monoamine oxidase inhibitor. Be careful of co-administration w/ SSRI for serotonin storm

Answer 4

Linezolid

Question 5

Can cause myelosuppression (thrombocytopenia), yeast superinfection, and mitochondrial toxicity in long courses

Answer 5

Linezolid

Question 6

Polymixin E antibiotic

Answer 6

Colistin

Question 7

Colistin regularly administered or prodrug?

Answer 7

Prodrug

Question 8

Colistin can cause ________toxicity and ________toxicity

Answer 8

Nephro

Neuro

Question 9

Phosphoric acid derivative

Answer 9

Fosfomycin

Question 10

Fosfomycin static or cidal?

Answer 10

Cidal

Question 11

Fosfomycin dosage?

Answer 11

3 gram oral packet of 1 dose

Question 12

Glycylcline agent

Answer 12

Tigecycline

Question 13

Tigecyline static or cidal?

Answer 13

Static

Question 14

Dose tigecycline achieve high serum conc?

Answer 14

NO

**Not good for bacteremia

Question 15

Lipopeptide

Answer 15

Daptomycin

Question 16

Daptomycin static or cidal?

Answer 16

Cidal

Question 17

Does daptomycin cover pneumonia?

Answer 17

No, inactivated by surfactant

Question 18

Causes side effect rhabdomyolysis and eosinophilic pneumonia (rare)

Answer 18

Daptomycin

Question 19

Irreversibly binds 50s. Individually static but cidal together. IV only

Answer 19

Quinupristin/Dalfopristin

Question 20

Glycolipopeptide. Semi-synthetic derivative of Vancomycin (be careful of cross sensitivity. May cause red man syndrome or nephrotoxicity like Vancomycin

Answer 20

Telavancin

Question 21

Cross rx with rifampin, tetracyclines, and ampicillin with _______

Answer 21

birth control