Uworld Exam 7

Question 1

Ether inactivates what kind of viruses?

Answer 1

enveloped

Question 2

After Ovulation, Secondary Oocyte is in what phase?

Answer 2

M2

Question 3

Different protein isoforms are created by?

Answer 3

Alternate RNA Gene Splicing

Question 4

An electrical wave by passing the AV node will change?

Answer 4

PR Interval

Question 5

WPW shows a triad. What are the Triad of electrical symptoms?

Answer 5

Shortened PR interval, a delta wave in QRS, widened QRS complex

Question 6

Th0=>induced to Th1 by?

Answer 6

IFN-gamma, and IL-12

Question 7

Th0=>induced to Th2 by?

Answer 7

IL-4

Question 8

Disulfiram Like Drugs?

Answer 8

Metronidazole, Griseofulvin, procarbazine and sulfonylureas

Question 9

When patient is unconscious, do you tell a family member about the condition?

Answer 9

Yes, Share the information if it is in the best interest of the patient

Question 10

Sensitivity identifies those with the disease? Yes or No?

Answer 10

Yes

Question 11

Methylated DNA and Acetylated DNA, what is the difference?

Answer 11

Methylated DNA mutes

Acetylated DNA activates

Question 12

SCLC marker?

Answer 12

Neuroendocrine origin=>Neurofilaments: enolase, chromogranin, synaptophysin

Question 13

Antidepressants Increase the risk for?

Answer 13

Inducing Mania

Question 14

Diffuse Gallbladder Calcifications; What should you do?

Answer 14

Porcelain gallbladder=>chronic cholecystitis; prophylatically remove due to increase risk of gallbladder cancer

Question 15

In Alzheimer’s Disease, what hydrocephalus do you see?

Answer 15

Hydrocephalus ex vacuo

Question 16

Oral Thrush on Tongue Tx?

Answer 16

Nystatin

Question 17

V/Q increased or decreased in apex and base?

Answer 17

Apex=>V/Q increases

Base=>V/Q decreases

Question 18

What pleura is for pain? And what nerves carry it?

Answer 18

Parietal Pleura, Phrenic Nerve

Question 19

Streptomycin MOA?

Answer 19

MOA: Binds to 30S ribosomal unit and blocks initiation of protein synthesis

Question 20

As you age what proteins do you lose?

Answer 20

Collagen and elastin

Question 21

Which cell CANNOT use Ketone bodies for energy?

Answer 21

erythrocytes

Question 22

Central Regulator of Iron homeostasis? MOA of regulation?

Answer 22

Hepicidin

MOA: Binds to Ferroportin and degrades it=>decreases iron absorption and does not allow macrophages to release iron

Question 23

Hepcidin increased in? Decreased? In what disease do you associate this with?

Answer 23

High Iron levels and inflammation increase levels
Hypoxia and erythropoiesis act to decrease levels
Anemia of Chronic Disease

Question 24

Does Health care proxy overrule all?

Answer 24

Yes

Question 25

Benzodiazepines MOA?

Answer 25

MOA: binds on allosteric site of GABAa=>increasing frequency (ion channel frequency); Ben Likes it more often, Barb likes it longer

Question 26

Baclofen MOA?

Answer 26

MOA: activates GABAb receptor=>G protein

Question 27

Two drugs that alter GABA metabolism?

Answer 27

Valproic acid and vigabetin=>reduce catabolism (reduce breakdown)

Question 28

Paroxsymal supraventricular tachycardia (PSVT) MOA? and epidemology?

Answer 28

MOA: re-entry impulse via slow and fast fibers | MC paroxsymal supraventricular tachycardia

Question 29

Carotid sinuses are innervated by what nerve?

Answer 29

CN 9

Question 30

Carotid Sinus Massage does what to the baroreceptor firing and what is the result?

Answer 30

Increases firing (hering nerve) and parasymp. influence prolongs AV refractory period

Question 31

Woman with Osteoporosis and HTN? Why?

Answer 31

HCTZ; increases Calcium (HyperGLUC)

Question 32

1st generation Antihistamines are?

Answer 32

Diphenhydramine, Dimenhydrinate, chlorpheniramine and promethazine Amine, nate, azine

Question 33

2nd generation Antihistamines are

Answer 33

Loratadine, fexofenadine, desloratadine and cetirizine | -adine or izine

Question 34

VZV histology?

Answer 34

Bx: Multinucleated inclusion-bearing giant cells

Question 35

Anabolic steriods (methyltestosterone) can lead to?

Answer 35

Acne

Question 36

What differentiates between Direct and Indirect Inguinal Hernia?

Answer 36

Inferior epigastric vessels

Question 37

Prostacyclins do what?

Answer 37

inhibit platelet aggregation

Question 38

HBV helps HDV (delta agent) in what way?

Answer 38

Delta agent is coated with HBsAg to get into cells

Question 39

With Chronic Lung Rejection, where do the immune rxn affect?

Answer 39

small airways

Question 40

What cytokine moves Smooth Muscle Cells from the Media to Intima? Who secretes it? What does it do?

Answer 40

PDGF and platelets; | migrates SMC from media to intima and proliferate in the intima

Question 41

Platelets secrete TGF-B. What does it do?

Answer 41

Smooth muscle cell chemotaxis and interstitial collagen production

Question 42

Lissencephaly results in? What do you see in MRI?

Answer 42

Results in: congenital absence of gyri | MRI: smooth brain

Question 43

Pseudotumor Cerebri what is the problem? What does it lead to?

Answer 43

Increased ICP with normal CSF and normal neuroimaging, optic nerve atrophy and blindness

Question 44

Spherules packed in spores

Answer 44

Coccidiodides immitis

Question 45

DM neuropathy is associated with?

Answer 45

Endoneural arteriole hyalinization

Question 46

Small Erythematous papules on the palms with excoriations, scattered vesicles and pustules on the finger webs, palms and wrist creases

Answer 46

Scabies mite and eggs

Question 47

Coffee Ground Color Indicates?

Answer 47

That the bleeding has touched acid=>oxidation of heme

Question 48

Increases in Preload do what to sarcomere length?

Answer 48

Increase

Question 49

Cleft Lip and palate, polydactyly, rockerbottom feet, holoprosencephaly

Answer 49

Trisomy 13

Question 50

Trisomy 13 Cause?

Answer 50

Meiosis I Non disjunction

Question 51

Coughing or Sneezing=>urine coming out; what kind of dysfunction is it?

Answer 51

Stress Urinary Incontinence=>Urethral Sphincter dysfunction

Question 52

Sudden Overwhelming Need to empty bladder; What kind of dysfunction is it?

Answer 52

Urge Incontinence=>Detrussor overactivity

Question 53

Constant involuntary dripping; What kind of dysfunction is it?

Answer 53

Overflow incontinence=>impair detrussor contractility