Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Uworld > Uworld Exam 12 > Flashcards

Uworld Exam 12 Flashcards

1
Q

What does Ubiquitin do? What is the result of a mutation in ubiquitin?

A

Ubiquitin=labels proteins for degradation by proteasomes

Mutation=>misfolded proteins accumulating

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

opioid withdrawal, what are its symptoms?

A

pupillary dilatation, rhinorrhea, sneeziing, nasal stuffiness, diarrhea

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Tx of opioid withdrawal?

A

Give some opioids

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

COX-1 helps maintain what?

A

gastric mucosa by mucous

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Main Reason to use a COX-2 Inhibitor (celecoxib)?

A

Prevent gastric ulcerations and reduced risk of bleeding

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

kinesin and dyenin are associated with what functional unit?

A

Microtubules

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Topoisomerase I and II do what?

A

relieve unwinding tension

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

RNA primase does what? What is its purpose?

A

provides a primer to free up a free 3’OH group

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What does DNA polymerase I do?

A

removes RNA primer and exonuclease

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What does DNA polymerase III do?

A

Causes elongation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Transformation is?

A

Taking up of naked DNA by cell

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Reassortment is?

A

Sudden Change in antigen by mixing two normal viruses

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Recombination is?

A

Defective viruses mixing and becoming virulent

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Linear Mucosal Tear in alcoholics with hematemesis?

A

Mallory Weiss Tear

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Transmural Mucosal Tear with esophageal air/fluid leakage NOT blood?

A

Boerhaave Syndrome

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Mallory Weiss Tear leads to what Acid Base disturbance?

A

metabolic alkalosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Phase 4 consists of spontaneous depolarizations that are due to what three things?

A
  1. K+ channel closure
  2. Na+ funny channel opening
  3. L-type Ca2+ channels opening
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Horseshoe kidney trapped by?

A

IMA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

What traps SMA?

A

Transverse duodenum

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

In Patients with myasthenia gravis, what other extramuscular abnormality exists?

A

abnormalities of the thymus (thymoma, thymic hyperplasia)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

Patient who complains of weakness and heaviness in her eyelids at the end of the day or an activity?

A

MG

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

What muscles are most susceptible in a patient with MG?

A

Extraocular muscles

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

Where does Thymus originate from? What other organ is with it in this pouch?

A

3rd pouch,

Inferior parathyroid glands

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

Spherules containing endospores?

A

Coccidioides

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
Who kills cells that don;t have MHC class I?
NK Cells
26
How do NK cells kill?
With Perforin and Granzymes to induce apoptosis
27
NK cells exhibit what CD?
CD 16 and 56
28
Are NK cells present in Athymic patients? Do they have memory?
Yes | No
29
NK cells are activated by what two cytokines?
IL-12 IFN-gamma
30
What ions regulate electrical potential?
Na, K and Cl
31
In resting membrane, where are the main ions located in a cell? Extracellular or Intracellular?
Na-Extracellular K-Intracellular Cl-Extracellular
32
Gram negative cocci in pairs suggests what organism?
Neisseria meningitidis
33
Best drug for prophylaxis of neisseria?
Rifampin
34
Rifampin MOA?
RNA
35
Coagulopathies like increased PTT or PT are from what kind of bleeding?
deep tissue bleeding-joints, muscles
36
Platelet defects shows as what kind of bleeding?
mucocutaneous bleeding (epistaxis, petechiae)
37
Prolonged PT? what pathway is wrong?
EX
38
Prolonged PTT? what pathway is wrong?
INT
39
Absolute Risk Reduction formula?
Event rate in Control-Event Rate in treatment
40
ALA synthase requires what cofactor?
B6
41
Passive Extension of the arm, there is initial resistance followed by a sudden release of tension as extension continued. What is this phenomenon called? Where do you see this symptom?
Clasp-knife spasticity | UMN Lesions
42
Internal capsule stroke will lead to what kind of symptoms?
Pure Motor: Contralateral arm, leg and lower face weakness
43
Lesion in caudate nucleus will lead to?
EPS symptoms like chorea and athetosis
44
QRS prolongation is due to what class of antiarrythmic drug?
Class 1
45
With a stable set of incidence, how do you increase prevalence?
Increased quality of care
46
Tet Spells help increase? To improve what?
systemic vascular resistance, oxygenation
47
With all urea cycle disorders, what do you food do you need to restrict?
Protein
48
Muscle weakness and fatigue with a particular ion?
K+
49
What 3 cytokines mediate inflammation?
IL-1, IL-6, and TNF alpha
50
LTB4, C5a, IL-8, 5-HETE are what kind of agents? These mediate the accumulation of?
chemotactic | Pus
51
anticoagulated RBCs fall at a rate of 35 mm per hour?
ESR
52
Sulfonyureas MOA?
MOA: bind to ATP dependent K+channels
53
Somatostatin is produced by?
D cells
54
Exogenous Insulin vs insulinoma?
Serum Insulin both elevated C-peptide decreased in Exogenous insulin BUT NOT in Insulinoma
55
Holoproscencephaly is due to?
Malformation
56
In chronic diabetics DM2 what do you see in their islet cells?
Amylin (amyloid)
57
DM is related to what HLA?
DR3, DR4
58
Neurological deficit, marked pallor (anemia)?
B12 def=>megaloblastic anemia
59
CN 7 has what symptoms?
1. Facial Motor Output symptoms 2. Parasymp. innervation to lacrimal, submandibular, sublingual 3. 2/3 of taste of tongue 4. external auditory canal
60
Live Attenuated Virus?
Live! One night only! See small yellow rotating chickens get vaccinated with Sabin and MMR! It’s incredible Smallpox, yellow fever, rotavirus, chickenpox (VZV), Sabin polio virus, MMR, Influenza (intranasal)
61
ABC Enzymes?
Pyruvate Carboxylase Propionyl Co-A Carboxylase Acetyl Co-A Carboxylase
62
Halothane AE?
Fulminant Hepatitis
63
T. Cruzi can cause?
Achalasia

Uworld (27 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions