Uworld Exam 4 Flashcards
What are fatty streaks? And do they predict atherosclerotic location?
Intracellular lipid accumulations=>but do not predict where atherosclerosis will happen.
MC Microcytic, hypochromatic anemia?
Iron Deficiency
Patient w/adrenal outer layer tumor, most likely symptom?
Hyperaldosteronism=>increased Na+ retention and K+secretion=>HTN and hypokalemia and alkalosis (H+ also secreted)=> think parathesia and muscle weakness
Cytokeratin + means?
Epithelial cells
HER2/neu receptors are what kind of receptors?
Tyrosine Kinase=>Growth factor receptor
Patient w/Recurrent episodes of sudden onset headaches followed by transient period then another headache. Next Step in Management?
24 hr urine metanephrines for Pheochromocytoma
Flat Facial features, and excessive skin in the back w/ VSD and duodenal atresia
Down Syndrome
SSRI MC AE?
AE: sexual dysfunction
OCP MOA?
decreased GnRH
Uteric Bud makes what structures? Metanephric Mesoderm (blastema)?
Uteric Bud=>Collecting Tubules=>ureters Metanephric Mesoderm (blastema)=> Glomerulus=>DCT
Rheumatoid Factor?
IgM Fc Region of human IgG (Non specific), anti-CCP (more specific)
Albinism, neurologic deficits and immunodeficiency. Dx? MOA of Dx? Bx?
Chediak-Higashi; MOA: Lysosomal fusion defect; Bx: giant cytoplasmic granules
Amitriptyline AE?
Cardiac arrythmias+antimuscarinic toxicity
Drugs in Drug induced lipids? What marker will be +? How are they metabolized in the body?
SHIPP (Sulfonamides, Hydralazine, Isonazid, Procainamide, Phenytoin); Antihistone ab
N-Acetylation in the Liver
Attributable risk percent in the exposed?
-Shows excess risk in the exposed population
ARP=100* (RR-1/RR)
Formula for Filtration Fraction?
FF=GFR/RPF
Without progesterone, endometrial lining sheds by what process?
apoptosis
A patient suddenly decelerates (“rear ending a vehicle”); There is a tear in which part of the aorta?
Isthmus of aorta
Best Test for asthma
methacholine challenge test
Best Test for asthma
methacholine challenge test
Multiple family members getting sick eating the same ethnic meal. The causal agent produces a spore, MOA?
Clostridium Botulinum=>Preformed Exotoxin**
MOA: Cleaves SNARE protein and blocks binding and fusion of Ach vesicles with plasma membrane=>inhibits the presynaptic release of Ach
Baby eats a jar of honey and gets Flaccid paralysis. What is the MOA of the casual agents’ virulence?
Clostridium Botulinum=>Ingestion of Spore**
Smoker w/SOB and cough and calcium elevated. What is the reason for elevated calcium?
Lung cancer (SCLC) that secretes parathyroid hormone related peptide (PTHrP)=>Most significant increase in hypercalcemia in malignancy
