Disease associated with neoplasm

Question 1

Acanthosis nigricans (hyperpigmentation and
epidermal thickening)

Answer 1

Visceral malignancy (esp. stomach)

Question 2

Actinic keratosis

Answer 2

Squamous cell carcinoma of skin

Question 3

AIDS

Answer 3

Aggressive malignant lymphomas (non-

Hodgkin) and Kaposi sarcoma

Question 4

Autoimmune diseases (e.g., Hashimoto
thyroiditis, SLE)

Answer 4

Lymphoma

Question 5

Barrett esophagus (chronic GI reflux)

Answer 5

Esophageal adenocarcinoma

Question 6

Chronic atrophic gastritis, pernicious anemia,

postsurgical gastric remnants

Answer 6

Gastric adenocarcinoma

Question 7

Cirrhosis

Answer 7

Hepatocellular carcinoma

Question 8

Cushing syndrome

Answer 8

Small cell lung cancer

Question 9

Dermatomyositis

Answer 9

Lung cancer

Question 10

Down syndrome

Answer 10

ALL (“we ALL fall Down”), AML

Question 11

Dysplastic nevus

Answer 11

Malignant melanoma

Question 12

Hypercalcemia

Answer 12

Squamous cell lung cancer

Question 13

Immunodeficiency states

Answer 13

Malignant lymphomas

Question 14

Lambert-Eaton myasthenic syndrome

Answer 14

Small cell lung cancer

Question 15

Myasthenia gravis, pure RBC aplasia

Answer 15

Thymoma

Question 16

Paget disease of bone

Answer 16

2° osteosarcoma and fibrosarcoma

Question 17

Plummer-Vinson syndrome ( iron)

Answer 17

Squamous cell carcinoma of esophagus

Question 18

Polycythemia

Answer 18

Renal cell carcinoma, hepatocellular carcinoma

Question 19

Radiation exposure

Answer 19

Leukemia, sarcoma, papillary thyroid cancer,

and breast cancer

Question 20

SIADH

Answer 20

Small cell lung cancer

Question 21

Tuberous sclerosis (facial angiofibroma,
seizures, intellectual disability)

Answer 21

Giant cell astrocytoma, renal angiomyolipoma,

and cardiac rhabdomyoma

Question 22

Ulcerative colitis

Answer 22

Colonic adenocarcinoma

Question 23

Xeroderma pigmentosum, albinism

Answer 23

Melanoma, basal cell carcinoma, and especially

squamous cell carcinomas of skin