UW 4-13-17 Flashcards

1
Q

What drug can reverse both the CNS and peripheral symptoms of severe atropine toxicity?

A

Physostigmine; neostigmine and edrophonium are quaternary structures and cannot cross BBB

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2
Q

What part of the CNS does leptin act on?

A

Arcuate nucleus

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3
Q

What are the actions of leptin?

A

Decreases NPY (decreasing appetite) and stimulates alpha-MSH (increasing satiety)

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4
Q

What type of response is seen in administration of the liver attenuated oral poliovirus vaccine?

A

More robust oropharyngeal and intestinal mucosal IgA response

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5
Q

What polio vaccine with produce a stronger mucosal secretory IgA immune response?

A

Live attenuated oral (Sabin)

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6
Q

What does the 4th aortic arch give rise to?

A

On left, the aortic arch; on right, proximal R subclavian artery

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7
Q

What does the 6th aortic arch give rise to?

A

Proximal pulmonary arteries; on left gives rise to ductus arteriosus

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8
Q

What is the vascular derivative of the first aortic arch?

A

Maxillary artery

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9
Q

What aortic arch does the common carotid artery come from?

A

Third

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10
Q

What aortic arch does the hyoid artery arise from?

A

Second

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11
Q

What vascular derivatives does the second aortic arch give rise to?

A

Stapedial artery; hyoid artery

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12
Q

What is the role of ATP in skeletal and cardiac muscle contraction?

A

Release myosin head from its actin binding site; energize conformational change that resets the myosin head to contract again the next time it binds to actin

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13
Q

What do the trocar and cannula pierce in a suprapubic cystostomy?

A

Layers of abdominal wall but will not enter the peritoneum (bladder is extraperitoneal)

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