CBSSA

Question 1

How do you calculate a loading dose?

Answer 1

(Target plasma concentration x volume of distribution) / bioavailability

Question 2

How do you treat neonatal pulmonary hypertension?

Answer 2

O2 to dilate pulmonary vasculature, mechanical vent and inhaled Nitric oxide

Question 3

What is the defective gene in Chediak Higashi?

Answer 3

Lysosomal trafficking regulator gene

Question 4

What is dysfunctional in Chediak Higashi syndrome?

Answer 4

Microtubule dysfunction in phagosome-lysosome fusion

Question 5

What is the inheritance of chediak higashi?

Answer 5

Autosomal recessive

Question 6

Patients with Chediak Higash are at increased risk for what?

Answer 6

Recurrent pyogenic infections by staphylococci and streptococci

Question 7

What is the inheritance pattern of acute intermittent porphyria?

Answer 7

Autosomal dominant

Question 8

What is the inheritance pattern of porphyria cutanea tarda?

Answer 8

20% are autosomal dominant

Question 9

What is seen 4 days after an MI?

Answer 9

Macrophages, then granulation tissue at the margins

Question 10

What type of necrosis is seen after an MI?

Answer 10

Coagulative necrosis

Question 11

What is the MOA of praziquantel?

Answer 11

Increases permeability to calcium ions

Question 12

What is the MOA of niclosamide?

Answer 12

Inhibits glucose uptake, oxidative phosphorylation, and anaerobic metabolism in a tapeworm

Question 13

What is the MOA of cisplatin?

Answer 13

Cross-link DNA