May 16

Question 1

What are the signs of congenital hypothyroidism?

Answer 1

Lethargy, poor feeding, constipation, hypotonia; can see umbilical hernia, protruding tongue, large anterior fontanelle

Question 2

What class of anti-arrhythmics has the phenomenon known as use-dependence?

Answer 2

Class IC; increased effect at faster heart rates

Question 3

What is the mechanism of PCP?

Answer 3

NMDA receptor antagonist

Question 4

A right nasal hemianopia can be caused by what? What is the location of the lesion?

Answer 4

Calcification or aneurysm of the internal carotid artery impinging on uncrossed, lateral retinal fibers; right peri-chiasmal lesion

Question 5

What vascular beds are most susceptible to atherosclerosis?

Answer 5

Abdominal aorta and coronary arteries

Question 6

What dopamine agonists are used in Parkinson disease?

Answer 6

Ergot - bromocriptine; nonergot - pramipexole and ropinirole

Question 7

What is the MOA of pramipexole?

Answer 7

Nonergot dopamine agonist

Question 8

What is the MOA of bromocriptine?

Answer 8

Ergot agonist

Question 9

What is the MOA of entacapone?

Answer 9

COMT inhibitor in the periphery

Question 10

What is the MOA of tolcapone?

Answer 10

COMT inhibitor centrally and peripherally

Question 11

Golden cytoplasmic granules in macrophages that turn blue with prussian blue staining?

Answer 11

Hemosiderin laden macrophages

Question 12

What are the symptoms of CMV in utero infection?

Answer 12

Chorioretinitis, sensorineural deafness, seizures, jaundice, hepatomegaly/splenomegaly, microcephaly

Question 13

What are the major causes of death due to lightning-related complications?

Answer 13

Fatal arrhythmias and respiratory failure