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Pharmacology II > Uterine, Thyroid, Osteoporosis - Indications, etc > Flashcards

Uterine, Thyroid, Osteoporosis - Indications, etc Flashcards

1
Q

DOC to induce labor at term. can prevent PPH

A

oxytocin

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2
Q

2nd line to decrease uterine bleeding

A

ergot alkaloids:

Ergonovine Maleate

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3
Q

What must occur before administration of Ergonovine Maleate?

A

uterine massage, oxytocin

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4
Q

Induces expulsion of uterine contents in fetal death, miscarriage, elective abortion…

A

Syth. PGs:

Dinoprostone/Carboprost/Misoprostol

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5
Q

Which synthetic PG can be used for cervical ripening at term?

A

Dinoprostone

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6
Q

3rd line for PPH after massage, oxytocin and ergots…

A

Syth. PGs:

Dinoprostone/Carboprost/Misoprostol

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7
Q

What uterine drug?

Reduce PPH by 20-30%

Tx of Uterine Bleeding via fibroids, non-partum causes.

A

Tranexamic Acid

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8
Q

What is the 1st line tocolytic to delay labor?

A

Magnesium Sulfate

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9
Q

What are two other indications for magnesium sulfate administration?

A

prevent pre-eclampsia convulsions

treat eclampsia

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10
Q

Which tocolytic is becoming 1st line to prevent pre-term labor/contractions?

A

indomethacin

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11
Q

Which tocolytic?

Use w. High-risk pregnancy w. Hx of preterm birth

A

Progesterone

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12
Q

Is progesterone an effective acute tocolytic therapy?

A

no

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13
Q

When is progesterone effective as a tocolytic agent?

A

given prophylactically from 16-37th week until delivery

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14
Q

The following are three adverse effects of…?

water intoxication, uterine rupture, fetal sinus bradycardia

A

oxytocin

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15
Q

What are two adverse effects of ergot alkaloids?

A

transient HTN, Angina/MI

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16
Q

What drugs have the following adverse effects?

N/V/Diarrhea
Fever/Chills/HA

A

Dinoprostone/Carboprost/Misoprostol

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17
Q

Which uterine drug can cause intravascular thrombosis?

A

Tranexamic Acid

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18
Q

the below are adverse effects of…

Flushing/Diaphoresis/Hypotension

Decreased DTRs/Paralysis/Weakness

Circulatory collapse/Cardiac/CNS/Respiratory Depression

A

Magnesium Sulfate

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19
Q

What is a major adverse effect of indomethacin?

A

partial closure of fetal ductus arteriosis

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20
Q

The below are 4 C/I for…

malpresentation
cephalopelvic disproportion
uterine/cervical scarring
unengaged head

A

Oxytoxcin

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21
Q

2 major contraindications for ergot alkaloid administration…

A

never to induce labor

PAD/CAD

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22
Q

The below are C/Is for what drugs?

Acute Cardio/Pulm/Renal/Hepatic Disease

Asthma, HTN, Anemia, Jaundice, Epilepsy

A

Synth PGs:

Dinoprostone/Carboprost/Misoprostol

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23
Q

DOC for hypothyroidism, must be carefully titrated to individual…

A

Levothyroxine

24
Q

Used in hypothyroidism as initial therapy due to faster steady state…

A

liothyronine

25
Q

What are adverse effects of levothyhroxine, liothyronine and dessicated thyroid?

A

thyrotoxicosis (hyperthyroid)

26
Q

What are four approaches to treating hyperthyroidism?

A

surgery, radioablation, pharm. decrease T3/T4, beta blockers (sxs)

27
Q

What is the 1st line tx for medical management of Graves?

A

Thioamides:

PTU/Methimazole

28
Q

There is a black box warning for PTU for what…

A

severe liver injury, acute liver failure

29
Q

In cases of severe liver injury/liver failure and Graves, what can you give instead of PTU?

A

methimazole

30
Q

Between PTU and methimazole, which is DOC in most cases?

A

methimazole

31
Q

When would you give PTU instead of methimazole for tx of hyperthyroidism?

A

Pregnancy, allergy

32
Q

Which drugs have the following adverse effects?

  • itching/skin rash
  • granulocytopenia/agranulocytosis
  • goiter
A

Thioamides: PTU and methimazole

33
Q

Which drug has the following indications for hyperthyroidism?

  • used 7-10 days before surgery to decrease risk of thyroid storm
  • used in radioactive emergency
A

Iodide

34
Q

What offers definitive tx for Graves, but is secondary to thioamides?

A

radioactive iodide

35
Q

This tx for hyperthyroidism is used in elderly patients or those with heart disease…

A

radioactive iodine

36
Q

What is the preferred tx for toxic nodular goiter?

A

radioative iodine

37
Q

Which drug will cause hypothyroidism and increases risk for thyroid storm?

A

radioactive iodine

38
Q

what can be given to decrease risk of thyroid storm when giving radioactive iodine?

A

thioamides

39
Q

What are the 3 contraindications for radioactive iodine?

A

pregnancy, nursing, mothers w/o childcare

40
Q

Which drug is used to decrease sxs of hyperthyroidism and to prepare for surgery before thioamides or radioactive iodine take effect?

A

beta blockers:

propranolol, metoprolol

41
Q

What is the contraindication for beta blocker use? What can be used instead?

A

C/I: Asthma

Use CCBs instead

42
Q

What is 1st line method of tx for hyperthyroidism/Graves?

A

pharmacologic tx

43
Q

What tx method of hyperthyroidism carries a high risk of thyroid storm?

A

radioactive iodine

44
Q

Caliconin has what two indications?

A

osteoporosis, pagets disease

45
Q

Which drug has the following adverse effects?

  • allergic rxn
  • rhinitis/sinusitis (IN)
  • N/V (IM)
A

calcitonin

46
Q

What are two adverse effects of teriparatide and abaloparatide?

A

hypercalcemia, hypercalciuria

47
Q

Teriparatide or Abaloparatide can cause hyperuricemia, and therefore shouldn’t be administered to gout patients?

A

abaloparatide

48
Q

What is the contraindication to teriparatide and abaloparatide?

A

osteosarcoma

49
Q

Denosumab has what two indications?

A

osteoporosis w. high fx risk

increase bone mass/strength in cortical and trabecular bone

50
Q

What are two contraindications for denosumab?

A

hypocalcemia

pregnancy

51
Q

What is the 1st line Tx for post-menopausal osteoporosis?

A

Bisphosphonates

52
Q

PO administration of bisphosphonates has what adverse effects?

A

GI sxs: pain, irritation, ulcer

53
Q

IV administration of bisphosphonates has what adverse effect if given quickly?

A

renal toxicity

54
Q

Bisphosphonates increase incidence of…

A

osteonecrosis of the jaw, atypical bone fx

55
Q

What are C/Is for oral and IV bisphosphonates?

A

PO: inability to stand/sit upright and esophageal disease

IV: renal disease

Pharmacology II (23 decks)

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