Endocrine: Sex Hormones, Names & Mechanisms Flashcards
What Class of Drugs?
Leuprolide (Lupron)
Long Acting GnRH Agonist
What Class of Drugs?
Cetorelix (Cetrotide)
GnRH Antagonist
What Class of Drugs?
hMG (Humegon)
Gonadotropin Mixtures (FSH)
What Class of Drugs?
hCH (Pregnyl)
LH
What Class of Drugs?
Estradiol (Estraderm)
Estrogen
What Class of Drugs?
Ethinyl Estradiol
Estrogen (only in mixed prep)
What Class of Drugs?
Conjugated Estrogen (Premarin)
Estrogen
What Class of Drugs?
Tamoxifen (Novaldex)
Antiestrogen
What Class of Drugs?
Raloxifene (Evista)
Antiestrogen
What Class of Drugs?
Clomiphene (Clomid)
Antiestrogen
What Class of Drugs?
Anastrozole (Arimidex)
Aromatase Inhibitor
What Class of Drugs?
Progesterone
Progestin
What Class of Drugs?
Medroxyprogesterone (Provera)
Progestin, progesterone derivative
What Class of Drugs?
Levonorgestrel (Plan B)
Progestin, 19-nortestosterone derivative
What Class of Drugs?
Mifepristone (RU 486, Mifeprex)
Antiprogestin
What Class of Drugs?
Drospirenone/Ethinyl Estradiol (Yasmin, Yaz)
Combo OC
What Class of Drugs?
Testosterone (Testoderm Transdermal)
Androgen
What Class of Drugs?
Flutamide (eulexin)
Anti-androgen
What Class of Drugs?
Spironolactone (Aldactone)
Anti-androgen
What Class of Drugs?
Finasteride (Propecia)
5-alpha-reductase inhibitors
Continuous admin → initial GnRH Surge → inhibition of GnRH
Leuprolide (Lupron)
Which drug has the following mechanism of action?
Low Dose: Antagonism of LH > FSH
High Dose: Antagonism of FSH > LH
Cetrorelix (Cetrotide)
Which drug has the following mechanism of action?
Binds FSH Receptors to induce FSH effects
hMG (Pergonal)
Which drug has the following mechanism of action?
Similar structure to LH → LH Receptor Binding
hCG (Pregnyl)
Which drug has the following mechanism of action?
Binds nuclear protein receptor → DNA transcription → ↑ transcription/translation → estrogen effects
Estrogens
Which drug has the following mechanism of action?
Selective Estrogen Receptor Modulator: Agonist in uterus & bone, antagonist in breast tissue → ↓ Bone Loss
Tamoxifen (Nolvadex)
Which drug has the following mechanism of action?
Selective Estrogen Receptor Modulator: Antagonist in breast & uterus, agonist in bone and liver → ↓ risk of uterine CA
Raloxifene (Evista)
Which drug has the following mechanism of action?
Selective Estrogen Receptor Modulator: Antagonist of estrogen in hypothalamus → Inhibition of Neg. Feedback → ↑ LH & FSH
agonist everywhere else
Clomiphene (Clomid)
Which drug has the following mechanism of action?
🚫 Conversion of Testosterone → Estradiol
🚫 Conversion of Androstendione → Estrogen
Anastrozole (Arimidex)
Which drug has the following mechanism of action?
Binds nuclear protein receptor → ↑ DNA Transcription/Translation → ↑ mRNA/Protein Synth → Progesterone effects
Progesterone
Which drug has the following mechanism of action?
Blocks progestin binding to progesterone receptor → prevention of implantation
Mifepristone (RU 486, Mifeprex)
Which drug has the following mechanism of action?
5x dose to inhibit implantation, exact mechanism unknown
Levonorgestrel (Plan B)
Which drug has the following mechanism of action?
Blocks binding of Testosterone and DHT to androgen receptor
Flutamide (Eulexin)
Which drug has the following mechanism of action?
Mineralcorticoid antagonist → competes with androgen & estrogen receptors
Spironolactone (Aldactone)
Which drug has the following mechanism of action?
Inhibits 5-alpha-Reductase → inhibition of T to DHT
Finasteride (Propecia)
