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Pharmacology II > Endocrine: Sex Hormones, Names & Mechanisms > Flashcards

Endocrine: Sex Hormones, Names & Mechanisms Flashcards

1
Q

What Class of Drugs?

Leuprolide (Lupron)

A

Long Acting GnRH Agonist

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2
Q

What Class of Drugs?

Cetorelix (Cetrotide)

A

GnRH Antagonist

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3
Q

What Class of Drugs?

hMG (Humegon)

A

Gonadotropin Mixtures (FSH)

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4
Q

What Class of Drugs?

hCH (Pregnyl)

A

LH

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5
Q

What Class of Drugs?

Estradiol (Estraderm)

A

Estrogen

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6
Q

What Class of Drugs?

Ethinyl Estradiol

A

Estrogen (only in mixed prep)

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7
Q

What Class of Drugs?

Conjugated Estrogen (Premarin)

A

Estrogen

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8
Q

What Class of Drugs?

Tamoxifen (Novaldex)

A

Antiestrogen

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9
Q

What Class of Drugs?

Raloxifene (Evista)

A

Antiestrogen

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10
Q

What Class of Drugs?

Clomiphene (Clomid)

A

Antiestrogen

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11
Q

What Class of Drugs?

Anastrozole (Arimidex)

A

Aromatase Inhibitor

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12
Q

What Class of Drugs?

Progesterone

A

Progestin

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13
Q

What Class of Drugs?

Medroxyprogesterone (Provera)

A

Progestin, progesterone derivative

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14
Q

What Class of Drugs?

Levonorgestrel (Plan B)

A

Progestin, 19-nortestosterone derivative

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15
Q

What Class of Drugs?

Mifepristone (RU 486, Mifeprex)

A

Antiprogestin

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16
Q

What Class of Drugs?

Drospirenone/Ethinyl Estradiol (Yasmin, Yaz)

A

Combo OC

17
Q

What Class of Drugs?

Testosterone (Testoderm Transdermal)

A

Androgen

18
Q

What Class of Drugs?

Flutamide (eulexin)

A

Anti-androgen

19
Q

What Class of Drugs?

Spironolactone (Aldactone)

A

Anti-androgen

20
Q

What Class of Drugs?

Finasteride (Propecia)

A

5-alpha-reductase inhibitors

21
Q

Continuous admin → initial GnRH Surge → inhibition of GnRH

A

Leuprolide (Lupron)

22
Q

Which drug has the following mechanism of action?

Low Dose: Antagonism of LH > FSH

High Dose: Antagonism of FSH > LH

A

Cetrorelix (Cetrotide)

23
Q

Which drug has the following mechanism of action?

Binds FSH Receptors to induce FSH effects

A

hMG (Pergonal)

24
Q

Which drug has the following mechanism of action?

Similar structure to LH → LH Receptor Binding

A

hCG (Pregnyl)

25
Q

Which drug has the following mechanism of action?

Binds nuclear protein receptor → DNA transcription → ↑ transcription/translation → estrogen effects

A

Estrogens

26
Q

Which drug has the following mechanism of action?

Selective Estrogen Receptor Modulator: Agonist in uterus & bone, antagonist in breast tissue → ↓ Bone Loss

A

Tamoxifen (Nolvadex)

27
Q

Which drug has the following mechanism of action?

Selective Estrogen Receptor Modulator: Antagonist in breast & uterus, agonist in bone and liver → ↓ risk of uterine CA

A

Raloxifene (Evista)

28
Q

Which drug has the following mechanism of action?

Selective Estrogen Receptor Modulator: Antagonist of estrogen in hypothalamus → Inhibition of Neg. Feedback → ↑ LH & FSH

agonist everywhere else

A

Clomiphene (Clomid)

29
Q

Which drug has the following mechanism of action?

🚫 Conversion of Testosterone → Estradiol

🚫 Conversion of Androstendione → Estrogen

A

Anastrozole (Arimidex)

30
Q

Which drug has the following mechanism of action?

Binds nuclear protein receptor → ↑ DNA Transcription/Translation → ↑ mRNA/Protein Synth → Progesterone effects

A

Progesterone

31
Q

Which drug has the following mechanism of action?

Blocks progestin binding to progesterone receptor → prevention of implantation

A

Mifepristone (RU 486, Mifeprex)

32
Q

Which drug has the following mechanism of action?

5x dose to inhibit implantation, exact mechanism unknown

A

Levonorgestrel (Plan B)

33
Q

Which drug has the following mechanism of action?

Blocks binding of Testosterone and DHT to androgen receptor

A

Flutamide (Eulexin)

34
Q

Which drug has the following mechanism of action?

Mineralcorticoid antagonist → competes with androgen & estrogen receptors

A

Spironolactone (Aldactone)

35
Q

Which drug has the following mechanism of action?

Inhibits 5-alpha-Reductase → inhibition of T to DHT

A

Finasteride (Propecia)

Pharmacology II (23 decks)

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