Endocrine: Sex Hormones, Names & Mechanisms

Question 1

What Class of Drugs?

Leuprolide (Lupron)

Answer 1

Long Acting GnRH Agonist

Question 2

What Class of Drugs?

Cetorelix (Cetrotide)

Answer 2

GnRH Antagonist

Question 3

What Class of Drugs?

hMG (Humegon)

Answer 3

Gonadotropin Mixtures (FSH)

Question 4

What Class of Drugs?

hCH (Pregnyl)

Answer 4

LH

Question 5

What Class of Drugs?

Estradiol (Estraderm)

Answer 5

Estrogen

Question 6

What Class of Drugs?

Ethinyl Estradiol

Answer 6

Estrogen (only in mixed prep)

Question 7

What Class of Drugs?

Conjugated Estrogen (Premarin)

Answer 7

Estrogen

Question 8

What Class of Drugs?

Tamoxifen (Novaldex)

Answer 8

Antiestrogen

Question 9

What Class of Drugs?

Raloxifene (Evista)

Answer 9

Antiestrogen

Question 10

What Class of Drugs?

Clomiphene (Clomid)

Answer 10

Antiestrogen

Question 11

What Class of Drugs?

Anastrozole (Arimidex)

Answer 11

Aromatase Inhibitor

Question 12

What Class of Drugs?

Progesterone

Answer 12

Progestin

Question 13

What Class of Drugs?

Medroxyprogesterone (Provera)

Answer 13

Progestin, progesterone derivative

Question 14

What Class of Drugs?

Levonorgestrel (Plan B)

Answer 14

Progestin, 19-nortestosterone derivative

Question 15

What Class of Drugs?

Mifepristone (RU 486, Mifeprex)

Answer 15

Antiprogestin

Question 16

What Class of Drugs?

Drospirenone/Ethinyl Estradiol (Yasmin, Yaz)

Answer 16

Combo OC

Question 17

What Class of Drugs?

Testosterone (Testoderm Transdermal)

Answer 17

Androgen

Question 18

What Class of Drugs?

Flutamide (eulexin)

Answer 18

Anti-androgen

Question 19

What Class of Drugs?

Spironolactone (Aldactone)

Answer 19

Anti-androgen

Question 20

What Class of Drugs?

Finasteride (Propecia)

Answer 20

5-alpha-reductase inhibitors

Question 21

Continuous admin → initial GnRH Surge → inhibition of GnRH

Answer 21

Leuprolide (Lupron)

Question 22

Which drug has the following mechanism of action?

Low Dose: Antagonism of LH > FSH

High Dose: Antagonism of FSH > LH

Answer 22

Cetrorelix (Cetrotide)

Question 23

Which drug has the following mechanism of action?

Binds FSH Receptors to induce FSH effects

Answer 23

hMG (Pergonal)

Question 24

Which drug has the following mechanism of action?

Similar structure to LH → LH Receptor Binding

Answer 24

hCG (Pregnyl)

Question 25

Which drug has the following mechanism of action? Binds nuclear protein receptor → DNA transcription → ↑ transcription/translation → estrogen effects

Answer 25

Estrogens

Question 26

Which drug has the following mechanism of action? Selective Estrogen Receptor Modulator: Agonist in uterus & bone, antagonist in breast tissue → ↓ Bone Loss

Answer 26

Tamoxifen (Nolvadex)

Question 27

Which drug has the following mechanism of action? Selective Estrogen Receptor Modulator: Antagonist in breast & uterus, agonist in bone and liver → ↓ risk of uterine CA

Answer 27

Raloxifene (Evista)

Question 28

Which drug has the following mechanism of action? Selective Estrogen Receptor Modulator: Antagonist of estrogen in hypothalamus → Inhibition of Neg. Feedback → ↑ LH & FSH agonist everywhere else

Answer 28

Clomiphene (Clomid)

Question 29

Which drug has the following mechanism of action? 🚫 Conversion of Testosterone → Estradiol 🚫 Conversion of Androstendione → Estrogen

Answer 29

Anastrozole (Arimidex)

Question 30

Which drug has the following mechanism of action? Binds nuclear protein receptor → ↑ DNA Transcription/Translation → ↑ mRNA/Protein Synth → Progesterone effects

Answer 30

Progesterone

Question 31

Which drug has the following mechanism of action? Blocks progestin binding to progesterone receptor → prevention of implantation

Answer 31

Mifepristone (RU 486, Mifeprex)

Question 32

Which drug has the following mechanism of action? 5x dose to inhibit implantation, exact mechanism unknown

Answer 32

Levonorgestrel (Plan B)

Question 33

Which drug has the following mechanism of action? Blocks binding of Testosterone and DHT to androgen receptor

Answer 33

Flutamide (Eulexin)

Question 34

Which drug has the following mechanism of action? Mineralcorticoid antagonist → competes with androgen & estrogen receptors

Answer 34

Spironolactone (Aldactone)

Question 35

Which drug has the following mechanism of action? Inhibits 5-alpha-Reductase → inhibition of T to DHT

Answer 35

Finasteride (Propecia)