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Pharmacology II > Endocrine: Sex Hormone Indications & Contraindications > Flashcards

Endocrine: Sex Hormone Indications & Contraindications Flashcards

1
Q

2 drugs that treat endometriosis…

A

Leuprolide (Long-Acting GnRH Agonist)

Cetorelix (GnRH Antagonist)

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2
Q

This drug is used to develop ovarian follicles and support estrogen synthesis

A

hMG (Exogenous FSH)

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3
Q

This drugs stimulates ovulation and leutinization …

A

hCH (Exogenous LH)

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4
Q

What therapy can be given to treat PMDD?

A

Drospirenone/Ethinyl Estradiol (Yaz)

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5
Q

Contraceptive has an 84 on, 7 off profile?

A

seasonale

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6
Q

What contraceptive has 84 on, 7 days estrogen?

A

seasonique

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7
Q

Which oral contraceptive is always on?

A

lybrel

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8
Q

Which implanted or non-oral contraceptive is intrauterine?

A

Mirena (levonorgesterel)

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9
Q

What contraceptive can be used during breast feeding?

A

progestin mini-pills

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10
Q

What two drugs can be used to treat female hypogonadism?

A

Conjugated Estrogen (Premarin) and Estradiol Cream/Patch (Estraderm)

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11
Q

Which drug is DOC in post-menopausal breast cancer treatment?

A

Anastrozole (aromatase inhibitor)

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12
Q

Which drug is used in pre-menopausal treatment of breast cancer?

A

Tamoxifen (SERM)

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13
Q

What drug class can be used to treat endometrial hyperplasia?

A

progesterone (progestins)

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14
Q

What two drugs are emergency contraceptives?

A

levonorgestrel, mifepristone

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15
Q

Which drug combo can be used to terminate pregnancy?

A

mifepristone + PGs

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16
Q

What drug can treat hirsutism?

A

spironolactone (MC antagonist)

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17
Q

What drug is used to treat female hypopituitarism?

A

testosterone

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18
Q

This drug is used to treat PCOS…

A

spironolactone (MC antagonist)

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19
Q

This drug can be used in the treatment of osteoporosis.

A

Raloxifene

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20
Q

These two drugs can be used to suppress sex characteristics until gender affirmation therapy

A

leuprolide, cetorelix

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21
Q

Which drug is used in M to F gender affirmation?

A

exogenous estrogen

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22
Q

Which drug is used in F to M gender affirmation?

A

testosterone

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23
Q

What three drugs are useful in precocious puberty?

A

Leuprolide, cetorelix

spironolactone

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24
Q

What therapeutic regimen can induce spermatogenesis

A

hCH (Pregnyl) → hMG (Humegon)

+

Testosterone

25
Q

This drug supports testosterone synthesis…

A

hCH (Exogenous LH)

26
Q

What is used to treat hypogonadism and testicular deficiency in males?

A

testosterone

27
Q

A negative nitrogen balance and nephrosis can be treated with…

A

testosterone

28
Q

Which two drugs can be used to treat prostate cancer?

A

Flutamide (Androgen receptor agonist) + Leuprolide (long-acting GnRH Agonist)

29
Q

Which drug is used to treat BPH?

A

finasteride (5 alpha reductase inhibitor)

30
Q

Which drug is used to treat male pattern baldness?

A

finasteride (5 alpha reductase inhibitor)

31
Q

What are the three oral contraceptives?

A

Progesterone + Estrogen

Drospirenone/Ethinyl Estradial (Yaz)

Natazia (bioidentical hormone)

32
Q

What are two adverse effects of leuprolide and cetorelix?

A

menopause sxs, testicular atrophy

33
Q

which hormone stimulates ovulation, follicle development, steroid production (T in men, E/Progestereone in women)?

A

LH

34
Q

For IVF, what is given for 9-12 days to stimulate ovaries and estrogen production?

A

FSH (hMG)

35
Q

For IVF, LH is given when and for what reason?

A

single dose to induce ovulation

36
Q

The following are three adverse effects of ______ administration?

ovarian hyperstimulation syndrome, multiple births, gynecomastia

A

hCG/hMG

37
Q

What are contraindications for hCG/hMG use?

A

sex steroid dependent cancers

38
Q

the below are adverse effects of _____

Migraines, endometrial hyperplasia, thromboembolism, accelerated blood clotting

A

estrogen

39
Q

What are 3 major contraindications for estrogen?

A

estrogen-dependent neoplasm, thromboembolic disorders, smoking over 35

40
Q

What are two contraindications to anastrozole? (aromatase inhibitor)

A

premenopause, pregnancy

41
Q

What are three adverse effects of aanastrozole/aromatase inhibitors?

A

GI sxs, hot flashes, joint pain

42
Q

Which drug converts the endometrial to a secretory state and helps maintain pregnancy?

A

progesterone

43
Q

The below are 3 adverse effects of _______?

increased BP, reduced HDL (high dose, 19-nortestosterone), depression/drowsiness

A

progestins

44
Q

three side effects of ________?

GI sx, abdominal/pelvic pain, vaginal bleeding

A

mifepristone

45
Q

When considering combo OC dosing, what is more important than the amount of hormone in each?

A

estrogen:progesterone ratio

46
Q

What are 5 COMMON adverse effects of combination OCs?

A 
breakthru bleeding
nausea
edema
depression
weight gain
47
Q

This drug is an MC antagonist used in combination oral contraception

A

drospirenone

48
Q

What are the CV problems associated with combination OCs? (4)

A

clotting
HTN
migraine
MI/Stroke

49
Q

What are 3 non-CV related serious side effects of combination OCs?

A

cholestatic jaundice/gallbladder disease

teratogenesis

fertility suppression

50
Q

Combination oral contraceptives can decrease risk of…

A

ovarian and endometrial cancer

51
Q

3 major absolute contraindications for combination OC use?

A

ASCVD
Thromboembolic pneumonia
Estrogen dependent cancers

52
Q

what is the major relative contraindication for combination OCs?

A

liver disease

53
Q

What are two major adverse effects of HRT?

A

small breast cancer risk, ASCVD/clotting

54
Q

What are three major advantages to HRT?

A

decrease menopause sxs, osteoporosis, heart disease

55
Q

When would HRT be most beneficial?

A

< 10 years after menopause onset

56
Q

What adverse effects of testosterone in men?

A

decreased spermatogenesis

57
Q

What are the adverse effects of testosterone in women?

A

masculinization, pseudohermaphroditism of fetus

58
Q

These are three major side effects of _____ use in both men and women…

oily skin/acne
decreased HDL
psych changes

A

testosterone

Pharmacology II (23 decks)

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