Endocrine: Sex Hormone Indications & Contraindications

Question 1

2 drugs that treat endometriosis…

Answer 1

Leuprolide (Long-Acting GnRH Agonist)

Cetorelix (GnRH Antagonist)

Question 2

This drug is used to develop ovarian follicles and support estrogen synthesis

Answer 2

hMG (Exogenous FSH)

Question 3

This drugs stimulates ovulation and leutinization …

Answer 3

hCH (Exogenous LH)

Question 4

What therapy can be given to treat PMDD?

Answer 4

Drospirenone/Ethinyl Estradiol (Yaz)

Question 5

Contraceptive has an 84 on, 7 off profile?

Answer 5

seasonale

Question 6

What contraceptive has 84 on, 7 days estrogen?

Answer 6

seasonique

Question 7

Which oral contraceptive is always on?

Answer 7

lybrel

Question 8

Which implanted or non-oral contraceptive is intrauterine?

Answer 8

Mirena (levonorgesterel)

Question 9

What contraceptive can be used during breast feeding?

Answer 9

progestin mini-pills

Question 10

What two drugs can be used to treat female hypogonadism?

Answer 10

Conjugated Estrogen (Premarin) and Estradiol Cream/Patch (Estraderm)

Question 11

Which drug is DOC in post-menopausal breast cancer treatment?

Answer 11

Anastrozole (aromatase inhibitor)

Question 12

Which drug is used in pre-menopausal treatment of breast cancer?

Answer 12

Tamoxifen (SERM)

Question 13

What drug class can be used to treat endometrial hyperplasia?

Answer 13

progesterone (progestins)

Question 14

What two drugs are emergency contraceptives?

Answer 14

levonorgestrel, mifepristone

Question 15

Which drug combo can be used to terminate pregnancy?

Answer 15

mifepristone + PGs

Question 16

What drug can treat hirsutism?

Answer 16

spironolactone (MC antagonist)

Question 17

What drug is used to treat female hypopituitarism?

Answer 17

testosterone

Question 18

This drug is used to treat PCOS…

Answer 18

spironolactone (MC antagonist)

Question 19

This drug can be used in the treatment of osteoporosis.

Answer 19

Raloxifene

Question 20

These two drugs can be used to suppress sex characteristics until gender affirmation therapy

Answer 20

leuprolide, cetorelix

Question 21

Which drug is used in M to F gender affirmation?

Answer 21

exogenous estrogen

Question 22

Which drug is used in F to M gender affirmation?

Answer 22

testosterone

Question 23

What three drugs are useful in precocious puberty?

Answer 23

Leuprolide, cetorelix

spironolactone

Question 24

What therapeutic regimen can induce spermatogenesis

Answer 24

hCH (Pregnyl) → hMG (Humegon)

+

Testosterone

Question 25

This drug supports testosterone synthesis...

Answer 25

hCH (Exogenous LH)

Question 26

What is used to treat hypogonadism and testicular deficiency in males?

Answer 26

testosterone

Question 27

A negative nitrogen balance and nephrosis can be treated with...

Answer 27

testosterone

Question 28

Which two drugs can be used to treat prostate cancer?

Answer 28

Flutamide (Androgen receptor agonist) + Leuprolide (long-acting GnRH Agonist)

Question 29

Which drug is used to treat BPH?

Answer 29

finasteride (5 alpha reductase inhibitor)

Question 30

Which drug is used to treat male pattern baldness?

Answer 30

finasteride (5 alpha reductase inhibitor)

Question 31

What are the three oral contraceptives?

Answer 31

Progesterone + Estrogen Drospirenone/Ethinyl Estradial (Yaz) Natazia (bioidentical hormone)

Question 32

What are two adverse effects of leuprolide and cetorelix?

Answer 32

menopause sxs, testicular atrophy

Question 33

which hormone stimulates ovulation, follicle development, steroid production (T in men, E/Progestereone in women)?

Answer 33

LH

Question 34

For IVF, what is given for 9-12 days to stimulate ovaries and estrogen production?

Answer 34

FSH (hMG)

Question 35

For IVF, LH is given when and for what reason?

Answer 35

single dose to induce ovulation

Question 36

The following are three adverse effects of ______ administration? ovarian hyperstimulation syndrome, multiple births, gynecomastia

Answer 36

hCG/hMG

Question 37

What are contraindications for hCG/hMG use?

Answer 37

sex steroid dependent cancers

Question 38

the below are adverse effects of _____ Migraines, endometrial hyperplasia, thromboembolism, accelerated blood clotting

Answer 38

estrogen

Question 39

What are 3 major contraindications for estrogen?

Answer 39

estrogen-dependent neoplasm, thromboembolic disorders, smoking over 35

Question 40

What are two contraindications to anastrozole? (aromatase inhibitor)

Answer 40

premenopause, pregnancy

Question 41

What are three adverse effects of aanastrozole/aromatase inhibitors?

Answer 41

GI sxs, hot flashes, joint pain

Question 42

Which drug converts the endometrial to a secretory state and helps maintain pregnancy?

Answer 42

progesterone

Question 43

The below are 3 adverse effects of _______? increased BP, reduced HDL (high dose, 19-nortestosterone), depression/drowsiness

Answer 43

progestins

Question 44

three side effects of ________? GI sx, abdominal/pelvic pain, vaginal bleeding

Answer 44

mifepristone

Question 45

When considering combo OC dosing, what is more important than the amount of hormone in each?

Answer 45

estrogen:progesterone ratio

Question 46

What are 5 COMMON adverse effects of combination OCs?

Answer 46

``` breakthru bleeding nausea edema depression weight gain ```

Question 47

This drug is an MC antagonist used in combination oral contraception

Answer 47

drospirenone

Question 48

What are the CV problems associated with combination OCs? (4)

Answer 48

clotting HTN migraine MI/Stroke

Question 49

What are 3 non-CV related serious side effects of combination OCs?

Answer 49

cholestatic jaundice/gallbladder disease teratogenesis fertility suppression

Question 50

Combination oral contraceptives can decrease risk of...

Answer 50

ovarian and endometrial cancer

Question 51

3 major absolute contraindications for combination OC use?

Answer 51

ASCVD Thromboembolic pneumonia Estrogen dependent cancers

Question 52

what is the major relative contraindication for combination OCs?

Answer 52

liver disease

Question 53

What are two major adverse effects of HRT?

Answer 53

small breast cancer risk, ASCVD/clotting

Question 54

What are three major advantages to HRT?

Answer 54

decrease menopause sxs, osteoporosis, heart disease

Question 55

When would HRT be most beneficial?

Answer 55

< 10 years after menopause onset

Question 56

What adverse effects of testosterone in men?

Answer 56

decreased spermatogenesis

Question 57

What are the adverse effects of testosterone in women?

Answer 57

masculinization, pseudohermaphroditism of fetus

Question 58

These are three major side effects of _____ use in both men and women... oily skin/acne decreased HDL psych changes

Answer 58

testosterone