Endocrine: DM Medications, Classes & Mechanisms Flashcards

1
Q

Lispro Class (humalog)

A

rapid acting insulin

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2
Q

Aspart Class (NovoLog)

A

rapid acting insulin

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3
Q

Glulisine Class (Apidra)

A

rapid acting insulin

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4
Q

Inhaled Regular Insulin Class (Afrezza)

A

rapid acting insulin

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5
Q

Regular Insulin Class (Novolin R, Humilin R)

A

Short Acting Insulin

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6
Q

NPH Insulin Class (Humulin N, Novolin N)

A

Intermediate Actin Insulin

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7
Q

Glargine class (lantus)

A

long acting insulin

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8
Q

detemir class (levemir)

A

long acting insulin

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9
Q

degludec class (tresiba)

A

long acting insulin

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10
Q

Glucagon drug class

A

insulin antagonist

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11
Q

diazoxide drug class

A

insulin antagonist

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12
Q

GLP-1 Receptor Agonists…

A

“tides”

Exenatide (Bayetta)
Liraglutide (Victoza)
Semaglutide (Rybelsus)

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13
Q

What class?

“gliptins”

Sitagliptin (Januvia)
Linagliptin (Tradjenta)

A

DPP-4 Inhibitors

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14
Q

What class?

“glitazones”

pioglitazone (actos)
rosiglitazone (avandia)

A

Thiazolidinediones (TZDs)

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15
Q

Alpha-Glucosidase Inhibitors…

A

Acarbose (precose)

miglitol (glyset)

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16
Q

3 Sulfonylureas

A

glyburide, glipizide, glimepiride

17
Q

Meglitinides/GLN…

A

Repaglinide (Prandin)

18
Q

Bile acid resin…

A

colesevelam (WelChol)

19
Q

DA agonist…

A

bromocriptine (cycloset)

20
Q

Amylin-like peptides…

A

pramlintide (symlin)

21
Q

What drug has the following mechanism?

↑ Blood Glucose via hepatic glycogen mobilization (if available)

Regulates glucose, AAs, FFA

A

Glucagon

22
Q

Diazoxide Mechanism:

A

Direct Inhibition of Insulin Secretion

Also: ↓ peripheral glucose utilization┃↑ hepatic glucose production

23
Q

Mechanism:

↓ Glucose independent of insulin (only reduces A1c by 0.5-1%)

A

metformin

24
Q

GLP-1 Receptor Agonists MoA

Exenatide, liraglutide, semaglutide

A

↑ Insulin Release (beta cells)

↓ Glucagon Release, ↓ hepatic gluconeogenesis (alpha cells)

25
Q

Mechanism: ↑ insulin release

Inhibition of DPP-4 → ↑ Action of incretins (GLP-1, GIP) via inhibition of breakdown

A

DPP-4 Inhibitors

Sitagliptin, Linagliptin

26
Q

Mechanism: Inhibits Sodium-Glucose Co-Transporter 2 in the Kidney

A

SGLT-2 Inhibitors

canagliflozin, dapagliflozin, empagliflozin

27
Q

TZDs MoA

pioglitazone, rosiglitazone

A

Mimics insulin signaling without requiring insulin

Increases GLUT4 in Adipose, Decrease Hepatic Glucose Production

28
Q

Mechanism:

Inhibition of intestinal alpha-glucosidases → delayed CHO digestion & absorption

↑ Bacterial CHO Fermentation → Gas

A

Alpha-Glucoside Inhibitors

Acarbose, Miglitol

29
Q

↑ Insulin Release

Mechanism: Bind/Block ATP Sensitive K+ channel → depolarization → ↑ Ca2+ influx in Beta Cells → ↑ Insulin Release

A

Sulfonylureas:
Glyburide, glipizide, glimepiride

Meglitinides/GLN:
Repaglinide

30
Q

Mechanism:

↑ Hypothalamic DA levels → Inhibits excessive SNS tone in CNS → ↓ hepatic glucose production → ↓ post-meal blood glucose

A

DA Agonist

Bromocriptine

31
Q

Mechanism:

Works w. Insulin to regulate postprandial glucose

↓ Gastric Emptying, postprandial glucose secretion, caloric intake via central modulation of appetite

A

Amylin-like peptide

pramlintide