Endocrine: Uterine, Thyroid, Osteoporosis Classes & Mechanisms

Question 1

What 3 drug classes are uterine stimulants

Answer 1

Oxytocin, Ergots, Prostaglandins

Question 2

What drugs class?

Dinoprostone, Carboprost Tromethamine, Misoprostol

Answer 2

prostaglandins

Question 3

What drug is an Ergot Alkaloid?

Answer 3

Ergonovine Maleate

Question 4

Which drug is a non-uterotonic drug?

Answer 4

tranexamic acid

Question 5

What drugs class?

Magnesium
Nifedipine (Procardia)
Indomethacin (Indocin)
Progesterone

Answer 5

tocolytic agents (uterine relaxation)

Question 6

Which drug has the following mechanism?

Cyclic Octapeptide Stored in Posterior Pituitary - Released w. Suckling & Cervical Pressure

Answer 6

Oxytocin

Question 7

Which drug has the following mechanism?

Uterine contraction via activation of serotonin and alpha receptors.

Answer 7

Ergot Alkaloids:

Ergonovine Maleate

Question 8

Ergonovine Maleate causes what type of contraction?

Answer 8

“always on” after labor/placenta delivery

Question 9

Which drug has the following mechanism?

anti-fibrinolytic → complete inhibition of plasminogen activation

Answer 9

Tranexamic Acid

Question 10

Which drug has the following mechanism?

Unknown mechanism - likely direct relaxation of uterus. Not FDA Approved for Pre-Term Labor

Answer 10

Magnesium Sulfate

Question 11

Which drug has the following mechanism?

Inhibit Ca2+ flux via blocking L-type Calcium Channels → 🚫 Smooth Muscle Contraction. Not FDA Approved for Pre-Term Labor

Answer 11

Nifedipine

Question 12

What is the mechanism of action for indomethacin?

Answer 12

Inhibit COX enzymes → 🚫 PG synthesis. Not FDA Approved for Pre-Term Labor

Question 13

Which drug has the following mechanism?

Inhibits Oxytocin and PG effects on uterus. Not FDA Approved for Pre-Term Labor, recommended by American College of OB/Gyn

Answer 13

Progesterone

Question 14

What three drugs are used in thyroid hormone replacement?

Answer 14

Levothyroxine
Liothyronine
Dessicated thyroid

Question 15

What are 4 inhibitors of thyroid hormone synthesis?

Answer 15

PTU, methimazole, iodide, radioactive iodine

Question 16

What are 2 beta blockers used in thyroid conditions?

Answer 16

propranolol, metoprolol

Question 17

Which thyroid drug has the following mechanism of action?

Sodium salt of T4, may produce normal levels of both T3 and T4

Answer 17

Levothyroxine

Question 18

The action of levothyroxine depends on…

Answer 18

peripheral deiodinase activity

Question 19

Which thyroid drug is a sodium salt of T3?

Answer 19

Liothyronine

Question 20

Which thyroid drug is a mix of T4 and T3 from pics?

Answer 20

dessicated thyroid

Question 21

Patients with a deficiency in peripheral deiodinases may respond better to which drug?

Answer 21

Dessicated thyroid

Question 22

which thyroid drug has the following mechanism of action?

Inhibits T4 synthesis by blocking conversion of T4 to T3

Answer 22

PTU

Question 23

which thyroid drug has the following mechanism of action?

Strongly inhibits T4 synthesis (more than PTU)

Answer 23

methimazole

Question 24

Because the effects of PTU and methimazole are gradual, what can be co-administered?

Answer 24

beta blockers

Question 25

How long will circulating T3/T4 last before inhibition by PTU and methimazole takes full effect?

Answer 25

1 weeks

Question 26

which thyroid drug has the following mechanism of action? Short-term, rapid decrease of synthesis and release of T4 and T3

Answer 26

iodide

Question 27

Large amounts of radioactive iodine has what effect? What about small amounts?

Answer 27

small/uCi = diagnostic large/mCi = destruction

Question 28

which thyroid drug has the following mechanism of action? inhibits peripheral conversion of T4 to T3 nonspecific beta blocker

Answer 28

Propranolol

Question 29

Which osteoporosis drug is a rank-ligand inhibitor?

Answer 29

denosumab

Question 30

What four drugs are bisphosphonates?

Answer 30

"-dronates": alendronate ibandronate risedronate zoledronic acid

Question 31

What three osteoporosis medications are PTH drugs?

Answer 31

teriparatide abaloparatide rhPTH

Question 32

What two substances should be the minimum tx for osteoporosis?

Answer 32

calcium and vit. D

Question 33

What are three hormone drugs used in osteoporosis?

Answer 33

estrogen, raloxifene, calcitonin

Question 34

Which osteoporosis drug has the following mechanism of action? Major mechanism is probably the inhibition of PTH secretion. May alter the physical-chemical properties of the bone mineral.

Answer 34

Calcium

Question 35

Which osteoporosis drug has the following mechanism of action? binds to a nuclear receptor, hence works through gene regulation for its effects. Increases GI calcium and phosphate absorption. must be adequate for optimal absorption of calcium.

Answer 35

Vitamin D

Question 36

Which osteoporosis drug has the following mechanism of action? inhibits bone resorption of calcium and phosphate by osteoclasts Antagonizes the actions of parathyroid hormone.

Answer 36

Calcitonin

Question 37

Teriparatide is an intermittent recombinant form of which hormone?

Answer 37

PTH

Question 38

Abaloparatide is a short recombinant form of what?

Answer 38

PTHrp

Question 39

rhPTH is a full length recombinant of...

Answer 39

PTH

Question 40

Which PTHR1 conformation is pro-osteoblast?

Answer 40

RG

Question 41

Which PTHR1 conformation is pro-osteoclast?

Answer 41

R0

Question 42

Which PTH drugs have the following mechanism of action? once daily admin to stimulate RG receptor → osteoblast activity

Answer 42

Teriparatide and Abaloparatide

Question 43

Which RG receptor stimulating drug has a 1600x affinity?

Answer 43

abaloparatide

Question 44

Which PTH drug has the following mechanism? binds R0 receptor to increase RANKL production → increased osteoclast activity

Answer 44

rhPTH

Question 45

Which osteoporosis drug has the following mechanism of action? Antibody to RANK-Ligand, the factor made by osteoblasts that is necessary for the formation of mature osteoclasts, leading to RANKL inhibition.

Answer 45

Denosumab

Question 46

Which osteoporosis drug has the following mechanism of action? P-C-P bond analogs of pyrophosphate Used as substitute for phosphate in calcium binding and is incorporated into bone inhibits osteoclast activity

Answer 46

bisphosphonates (-dronates)