Intro to CV/Renal Pharm Flashcards
Which Cholinergic Receptor Type?
Excitatory
Found on:
- CNS Neurons
- SNS postganglionics
- Some presynaptic
Signal Transduction Mechanism:
- form DAG & IP3 –> increased Ca
M1
Which Cholinergic receptor type?
Inhibitory
Found on:
-Myocardium, smooth muscle, pre-synaptic
Signal Pathway:
-De-phosphorylation of Ca2+ channels
- Phosphorylation and opening of K+ channels
- inhibits adenylyl cyclase
M2
Which Cholinergic Receptor Type?
Excitatory
Found on:
- Exocrine glands
- smooth muscle
- endothelial vessel tissue
M3
Which Adrenergic Receptor Type?
Inhibitory
Found on:
- Presynaptic adrenergic nerves
- platelets
- lipocytes
- smooth muscle
Signal Pathway:
-De-phosphorylation of Ca2+ channels
- Phosphorylation and opening of K+ channels
- Inhibits adenylyl cyclase, ↓cAMP concentration
Alpha 2
Which Adrenergic Receptor Type?
Excitatory
Found on:
-Postsynaptic effector cells of heart, lipocytes, brain
-Presynaptic adrenergic and cholinergic nerves
Signal Pathway:
-Stimulates adenylyl cyclase → ↑cAMP
Beta 1
Which Adrenergic Receptor Type?
Excitatory
Found on:
-Postsynaptic smooth muscle and cardiac muscle cells
Signal Pathway:
-Stimulates adenylyl cyclase → ↑cAMP
Beta 2
Which Adrenergic Receptor Type?
Excitatory
Found on:
-Postsynaptic lipocytes
Signal Pathway:
-Stimulates adenylyl cyclase → ↑cAMP
Beta 3
Which Dopaminergic Receptor?
Excitatory
Found on:
-Brain, effector tissues of renal vascular bed
Signal Pathway:
-Stimulates adenylyl cyclase → ↑cAMP
D1
Which Dopaminergic Receptor Type?
Inhibitory
Found on:
-Brain, smooth muscle, presynaptic nerve terminals
Signal Pathway:
-De-phosphorylation of Ca2+ channels
- Phosphorylation and opening of K+ channels
- Inhibits adenylyl cyclase, ↓cAMP concentration
D2
Predominant Tone in the SA Node is _____ on the _____ receptor. this leads to…
PNS Tone on M2 Receptor
Leads to ↓ HR
Predominant tone in the skin and splanchnic vessels is _____ on the ____ receptor(s) leading to…
SNS tone on alpha receptors
Leads to vasoconstriction
Which type of neuron has the following presynaptic receptors?
α2 (Autoreceptor)
M2 (Heteroreceptor)
SNS neurons
Which type of neuron has the following presynaptic receptors?
α2 (Heteroreceptor)
M2 (Autoreceptor)
PNS Neurons
Which type of presynaptic receptor has the following characteristics?
Stim by: NE
Action: Block NE release
α2
Which type of presynaptic receptor has the following characteristics?
Stim by: ACh from PNS neuron
Action: Block NE release
M2
