Uterine Leiomyomas

Question 1

What is the major symptoms associated with fibroids?

Answer 1

heavy menstrual bleeding, thought to be secondary to: 1)an increase in uterine cavity size that leads to greater surface area for endometrial sloughing and/or 2)obstructive effects on uterine vasculature that leads to endometrial venule ectasia and proximal congestion in myometrium/endometrium resulting in heavy menstrual bleeding;;;other symptoms include pain and pressure related to size of tumors

Question 2

what are the most common solid pelvic tumors in women?

Answer 2

uterine fibroids

Question 3

Which type of myomas are most likely to cause lower pregnancy and implantation rates and why?

Answer 3

submucosal or intracavitary myomas; 1)focal endometrial vascular disturbance 2)endometrial inflammation 3)secretion of vasoactive substances

Question 4

What happens when using GnRH agonist treatment for myomas?

Answer 4

mean uterine size decreases 30 to 64% after 3 to 6 months of use; it decreases release of estrogen

Question 5

reduction in myoma size with GnRH use correlates with?

Answer 5

estradiol level and with body weight