Urinary Incontinence Flashcards
Risk factors for overactive bladder
Age >40 yeas old, Diabetes, Prior vaginal delivery, Drugs that increase incontinence
how is the detrosor muscle inervated
parasympathetic nervous system via acetylcholine acting on the muscarining receptors
In urinary urgency what happens
inappropriate stimulation of muscarinic receptors on the detrusor causes involuntary contractions and the feeling
what is the m3 receptor responsible for
emptying contractions and involuntary blader contractors
1st line drugs for incontinence
anticholinergics or a beta-3 receptor agonist
highest efficacy for incontinence
botox (onabotulinum toxinA) but requires injection
pseudoephrine side effects
tachycardia, palpitations
moa of anticholinergic drugs
aka antoimuscarinics, block ACH from binding
which anticholinergic drugshave fewer CNS side effects
selective for m3 receptor
which type of drug has lower risk of dry mouth
ER
Diotropan
Oxybutynin
Detrol
Toleterodine
Vesicare
Solifenacin
What meds can leave a ghost cell in the stool
diotropan XL (oxybutinin) and from last chapter cardura XL
if you have what condition should you avoid anticholinergic drugs
glaucoma and BPH
