Oncology 1 part 1 Flashcards
Draw Chemoman
see pg 813
Bleomycin lifetime dose
400 units due to pulmonary toxicity
Doxorubicin Lifetime Dose
450-550 mg/m2 due to cardiotoxicity
Cisplatin lifetime dose
Dose per cycle not to exceed 100 mg/m2 due to nephrotoxicity
Vincristine max dose
Single dose capped at 2mg due to neuropathy
BSA (m2)=
square root of ht (cm) * wt (kg) / 3600
what is given to prevent cardiotoxic effect from doxorubicin
dexrazoxane
M in chemo man
methotrexate –> causes mucositis (so does flurouracil)
which chemo drugs do not cause myelosupression
asparagomase, bleomycin, vincristine
What can be given with irnotecan for early onset diarrhea
atropine
what should be given with cisplatin to reduce the risk of nephrotoxicity
amifostine (ethyol), also hydration
which drugs can increase risk of cloitting
Aromatase inhibitors (anastrozole, letrozome) and SERMS (tamoxifen and raloxifine)
What is given with methotrexate to decrease myelosupression and mucositis in high doses therapy
leucovorin (folic acid also given)
What is given as an antidote to methotrexate due to acite renal failure
glucarpidase
N stands for
Nitrosoureas (Lomustine, Carmustine) - CNS toxicity
C stands for
platinum based (i.e. cisplatin, carboplatin) –> nephrotoxicity/ototoxicity
ethyol
amiofistine, the drug that is given prophylactically to reduce neporptoxicity risk with cisplatin
B stands for
Bleomycin, Busolfan, Carmustine, Lomustine —> pulmonary fibrosis
D stands for
Doxarubicin and other anthracyclines –> Cardiotoxic
IP
Ifosfamide and cyclophosphammide –> hemmorhagic cystitis (bladdes oozes blood)
What is given with Ifosfamide and higher doses of cyclophosphamide to prevent hemorrhagic cystitis
Mesna (Mesnex) and fluids
What does VT stand for
Vinca Alkaloids (Vincristine, Vinblastine & Vinorelbine) and taxanes (paclitaxel, docetacel)
What does BMS stand for
Bone marrow supression - ALL except vincristine, bleomycin, monocolonial antibodies (because they are targeted), and TKI’s
which chemo drug is known to cause bad diarrhea
irinotecan (i run to the can)
also
capecitabine, flurouracil, methotrexate
ANC = what equation
Neutropenia vs severe neutromenia
WBC * (seg% + band%)/100
Neutropenia = ANC less than 1000 cells/mm3
Severe neutropenia = ANC less than 500 cells/mm3
neupogen
filgrastim
neulasta
pegfilgrastim
