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My own Naplex > Oncology 1 part 2 > Flashcards

Oncology 1 part 2 Flashcards

1
Q

low white blood cells cause

A

leukopenia, increased infection risk

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2
Q

Low rbcs cause

A

anemia, with weakness and fatigue

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3
Q

low platelets cause

A

thrombocytopenia, with high risk of severe/uncontrolled bleeding

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4
Q

lowest point that wbcs and platelets reach is called what and occurs hwow long after chemo

A

nadir, usually occurs 1-2 weeks after chemo with the rbc nadir being much longer at 120 days (4 months)

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5
Q

how long does it take for both rbc an dplatelets to recover

A

3-4 weeks

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6
Q

What do CSF stimulate

A

WBC’s - pegfilgastrim and filgastrom

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7
Q

what do EPO stimulate

A

RBC, but rarely used because decrease surival (darbapoetin and epopoetin)

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8
Q

platelet cutoff for transfusion

A

less than 10,000

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9
Q

side effect of csf and monitoring

A

achy bones and joints, fever, myalgias, rash

report any sign of enlarged slpeeen, document when pegfilgastram was given

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10
Q

fever cutoff for neutropenia

A

38.3 (101)

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11
Q

celcius to farenheit equation

A

F = C * 1.8 +32

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12
Q

oral anti pseudomonal prophylaxis regimen

A

ciprofloxacin or levofloxacin

plus

augmentin or clindamycin (if allergic to penicillin)

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13
Q

IV anti pseudomonal regimen

A

cefepime

or

ceftazidime

or

carbopenem (except ertapenem

or

zozyn

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14
Q

what are all the pseudomonas covering antibiotics

A

Cefepime (4th gen), ceftazidime (3rd gen)

Carbopenems (except ertapenem)

Quinolones (levofloxacin, ciprofloxacin)

Aminoglycosides (gentamicin, tobramicin, amikacin)

Zozyn

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15
Q

Which factors increase risk of chemo induced nausea and vomiting

A

female gender

<50 years age

dehydration

hx of motion sickness and hx of nausea and vomiting

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16
Q

acute nausea onset and tx

A

within 24 hours of chemi, 5ht3 receptor antagonists preferred

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17
Q

delayed onset tx

A

greater than 24 hours after chemo, nk1-RA, corticosteroids, palosetron (h5t3), and olanzapine(other) preferred

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18
Q

anticipatory nausea tx

A

benzo the evening prior to chemo preferred

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19
Q

what regimen to give with cisplatin

A

highly emetogenic - give 3 or 4 drugs from each category

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20
Q

5ht3a main side effects

A

headaches and constipation

21
Q

main side effects of dopamine receptor antagonists (such as prochlorperazine, promethazime, and metoclopramide)

A

sedation, EPS

22
Q

droperidol has what risk

A

QT prolongation

23
Q

emend

A

apirepitant or fosaprepitant

24
Q

zofran

A

ondanetron

25
Q

zuprenz film

A

ondansetron

26
Q

sancuso

A

granisetron

27
Q

Aloxi

A

Palonosetron

28
Q

Akynzia

A

fosnetupitant and palonosetron IV

29
Q

decadron

A

dexamethasone

30
Q

Compazine

A

prochlorperazine

31
Q

phenergan

A

promethazine

32
Q

reglan

A

metoclopramide

33
Q

zyprexa

A

olanzapine

34
Q

marinol

A

dronabinol

35
Q

cesamet

36
Q

ativan

37
Q

miacalcin

A

calcitonin

38
Q

zometa

A

zolendroic acid

39
Q

xgeva

40
Q

aprepitant and fosprepitent are what moa

A

NK-1RA (receptor agonists)

41
Q

apomorphine for parkinson’s should not be used with what

A

5HT3 antagonists

42
Q

overdose of metoclopramide can cause what

A

Tardive diskinesia

43
Q

age cutoff for promethazine

A

2 years old

44
Q

promethasine contraindication

A

do not give intra arterial or SC because can cause serious tissue injury if excavision occurs

45
Q

why is droperidol no longer comminly used

A

high QT risk

46
Q

hand foot syndrome is usually caused by what

A

capcitabine, fluorouracil

47
Q

Chemotherapy agents that are vesicants

A

anthracyclines and vinka alkaloids

48
Q

dexrazocane (totect) and dimethyl sulfoxide are what

A

antidotes for anthracycline extraversion

49
Q

hyluronidase is what

A

an antidote for vinka alkaloids and etoposide extraversion

My own Naplex (39 decks)

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