urea cycle Flashcards
what does the urea cycle do
converts NH4 to urea
where does it occur
the liver
what are the precursors of urea
NH4
CO2
aspartate
what happens to urea once produced
gets secreted into blood, then kidneys, then peed out
what enzyme funnels carbomyl phosphate into cycle
CPS1
where does the formation of carbomyl phosphate occur
mitochondria
what is CPS 1 allosterically regulated by
N acetylglutamate
what is the formation of carbomyl phosphate (3)?
how many ATP molecules does this reaction need
bicarbonate
carboxyphosphate
carbonic acid
carbomoyl phosphate
2 ATP molecules
what does N-acetylglutamate synthase do
makes n-acetylglutamate from acetyl coa and glutamate
what is the first reaction of the urea cycle catalyzed by
ornithine transcarbamolase
what is the first reaction of the urea cycle
ornathine + carbomoyl phosphate being added by ornithine transcarbamoylase to make citrulline
where do the where does the second nitrogen come from in urea
aspartate
what enzyme catalyses the reaction of the second nitrogen onto argininosuccinate
argininosuccinate synthetase
what enzyme produces fumarate as a product
argininosuccinase
what does the urea cycle supply a lot of for adults
arginine
