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BMSC230 > pyrimidine metabolism > Flashcards

pyrimidine metabolism Flashcards

1
Q

what are pyrimidine nucleotides essential for

A

RNA and DNA synthesis

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2
Q

what are some pyrimidine nucleotides

A

UMP
CTP
TTP

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3
Q

what is ATCase allosterically regulated by

A

CTP and ATP

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4
Q

what does CTP do to ATCase

A

inhibits it

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5
Q

what is PRPP synthesis regulated by?

A

purine nucleotides, not pyrimidines

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6
Q

what does ribonucleotide reductase do

A

converts ribonucleotides to deoxyribonucleotides (which are required for DNA synthesis)

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7
Q

what does Ribonucleatide reductase used to reduce nucleotides

A

NADPH

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8
Q

what is dTMP formed from

A

dUMP

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9
Q

how does dTMP become dUMP

A

addition of 1 carbon unit (from N5,N10) from dUMP to dTMP

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10
Q

what is 5-fluorouracil to thymidylate synthase

A

a suicide inhibitor

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11
Q

what enzyme is involved in the conversion of dUMP to dTMP

A

thymidylate synthase

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12
Q

what is tetrahydrofluorides role in pyrimidine metabolism

A

it donates 1 carbon units needed for thymidylate and purine synthesis

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13
Q

what does the enzyme (thymidylate synthase) that converts dUMP to dTMP require?

A

N5,N10 methylene THF to transfer one carbon unit to dUMP

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14
Q
A
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15
Q

what is dTMP needed for

A

DNA synthesis

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16
Q

what is also generated in the reaction of dUMP to dTMP

A

dihydrofolate

17
Q

what does dihydrofolate do

A

regenerates tetrahydrofolate

18
Q

what inhibits dihydrofolate reductase? whats the harm of that

A

methotrexate

it stops the reformation of tetrahydrofolate

19
Q

what does ATCase catalalyze

A

Aspartate + Carbamoyl phosphate (and PRPP) to orotate

20
Q

what is the backbone for both purines and pyrimidines

A

PRPP (phosphoribosyl pyrophosphate)

21
Q

what converts UTP to CTP

A

Cytidylate synthetase

22
Q

what does the formation of CTP from UTP require

A

ATP, nitrogen from glutamine, and the enzyme cytidylate synthetase

23
Q
A

BMSC230 (24 decks)

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