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BMSC230 > purine metabolism > Flashcards

purine metabolism Flashcards

1
Q

which two drugs stop the synthesis of viral genomes usually in herpes

A

acyclovir
azidothymine

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2
Q

what do purines have

A

adenine and guanine

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3
Q

go look at the purine synthesis picture

A
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4
Q

whats an important intermediate in purine synthesis

A

IMP (inosinate)

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5
Q

when does the purine pathway converge into 2 pathways ?

A

at IMP

can go to adenine or guanine

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6
Q

whats the first step in purine synthesis

A

PRPP gets converted to 5-phospho-b-D-ribosylamine by the enzyme glutamine-PRPP amidotransferase

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7
Q

whats different for the formation of ring synthesizing between pyrimidines and purines

A

pyrimidines - the R5P gets added after the ring gets synthesized
purines - the ring gets synthesized onto the R5P

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8
Q

what pathway uses GTP

A

IMP to AMP

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9
Q

what pathway uses ATP

A

IMP to GMP

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10
Q

what is the purine precursor

A

inosite (IMP)

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11
Q

whats the major regulatory point (enzyme) in purine biosynthesis

A

glutamine PRPP Amidotransferase (first step)

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12
Q

what inhibits glutamine PRPP amidotransferase

A

IMP, AMP, GMP

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13
Q

where do the two pathways to uric acid converge

A

xanthine

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14
Q

what happens to xanthine? whats the enzyme

A

gets oxidized to uric acid by xanthine oxidase

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15
Q

why is uric acid bad

A

it is insoluble so it crystallizes and can lead to gout

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16
Q

what is allopurinol used for

A

gout treatment

17
Q

how does allopurinol work

A

it reacts with xanthine oxidase to produce oxypurinol which inhibits xanthine oxidase

18
Q

what does the salvage pathway do

A

purine bases get recycled to form purine nucleotides without having to fully synthesize them from scratch

19
Q

PRPP + adenine =
(also whats the enzyme )

A

AMP
APRT

20
Q

PRPP + guanine =
(also whats the enzyme)

A

GMP
HGPRT

21
Q

PRPP + hypoxanthine =
(whats enzyme)

A

IMP
HGPRT

22
Q

what leads to leech nyhan syndrome

A

a defect in the enzyme HGPRT

BMSC230 (24 decks)

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