amino acid/nucleotide synthesis Flashcards

1
Q

what are the reactions in amino acid/nucleotide synthesis

A

1 carbon transfer reactions

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2
Q

what does S-adenosyl methionine do

A

donates a methyl group

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3
Q

whats the principle molecule used in amino acid/nucleotide synthesis

A

tetrahydrofolate

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4
Q

can we make tetrahydrofolate

A

no

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5
Q

where do the carbon 1 units get added on tetrahydrofolate

A

N5 and N10

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6
Q

what section is the N5 on

A

6-methypterin

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7
Q

what section is the N10 on

A

p-aminobenzoate

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8
Q

what does homocysteine become

A

methionine with the addition of N5

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9
Q

whats the substrate of methionine synthase

A

homocysteine

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10
Q

what does glycine become

A

serine with the addition of N5, N10

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11
Q

what is methionine the precursor of

A

S-adenosylmethionine

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12
Q

whats the most important methyl donor in metabolic reactions

A

S-adenosylmethionine

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13
Q

methionine + ATP becomes what

A

S-adenosylmethionine

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14
Q

how is S-adenosylmethionine linked to methionine

A

at the C5 ribose atom

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15
Q

where does the methyl group on methionine come from

A

N5

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16
Q

CH3

A

methyl

17
Q

CH2

A

methylene

18
Q

CHO

A

formyl

19
Q

what happens if serine binds to 3-phosphoglycerate dehydrogenase

A

it inhibits it and shuts the creation down

20
Q

what are valine and isoleucine used for

A

protein synthesis

21
Q

what enzymes are created together usually

A

valine and isoleucine

22
Q

what does isoleucine do to threonine deaminase

A

inhibits it

23
Q

what does valine do to threonine deaminase

A

activates it

24
Q

what enzyme converts threonine to a-ketobutyrate

A

threonine deaminase