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BMSC230 > metabolism of nucleotides > Flashcards

metabolism of nucleotides Flashcards

1
Q

what are the precursors of DNA

A

dATP
dGTP
dCTP
dTTP

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2
Q

what are the precursors of RNA

A

ATP
GTP
CTP
UTP

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3
Q

what is the energy currency in biological systems

A

ATP

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4
Q

what are components of 3 major coenzymes

A

adenine nucleotides

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5
Q

what are adenine nucleotides components of

A

NAD
FAD
coenzyme A

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6
Q

what is CTP used n

A

the biosynthesis of glycerophospholipids

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7
Q

what pathways produce nucleotides

A

de novo pathway
salvage pathway

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8
Q

what are pyrimidines built from

A

carbamoyl phosphate
aspartate
PRPP

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9
Q

where does the nitrogen of cystolic carbamoyl phosphate come from

A

glutamine

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10
Q

whats the rate limiting step in pyrimidine synthesis

A

synthesis of carbamoyl phosphate

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11
Q

where is CPS2 located

A

cytosol

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12
Q

what is CPS2 used for

A

synthesis of pyrimidines

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13
Q

what enzyme synthesizes carbamoyl phosphate in pyrimidine synthesis

A

CPS2

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14
Q

what inhibits ATPase

A

CTP

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15
Q

what inhibits CPS2

A

UTP

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16
Q

what does aspartate + carbamoyl phosphate make

A

carbamoylaspartate

17
Q

what enzyme catalyzes the reaction to carbamoylaspartate

A

ATCase (aspartate transcarbamoylase)

18
Q

what is the mot important allosertically regulated thing in pyrimidine synthesis

A

ATCase

19
Q

what do synthetase enzymes require

A

energy in the form of ATP

20
Q

what do synthase enzymes require

A

no energy required

21
Q

what are the precursors of the pyrimidine ring

A

R5P
CO2
Glutamine
Asparate

22
Q

what are the 2 things that are regulated in pyrimidine synthesis

what is the critical regulatory point

A

ATCase
CPS2

ATCase is the critical one

23
Q

what enzyme closes the ring? what does it also yield

A

duhydroorotate synthase

BMSC230 (24 decks)

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