pyruvate dehydrogenase complex Flashcards
what is the pyruvate dehydrogenase complex
private to acetyl Coa
what is the pyruvate dehydrogenase complex
a complex of three enzymes that catalyze 5 reactions
what does the pyruvate dehydrogenase complex
require
5 different cofactors
what happens to pyruvate through the pyruvate dehydrogenase complex?
it gets oxidized and a carboxyl group gets removed (oxidative decarboxylation)
where is the pyruvate dehydrogenase complex (PDH) present
the mitochondria
what does the MPC (mitochondrial pyruvate transporter) do?
helps pyruvate get into the mitochondria
what are the two electron carriers in the pyruvate dehydrogenase complex? how many electrons do they carry each?
FADH2 and NADH - 2 electrons each
what is thiamine pyrophosphate
a transient carrier (one of the cofactors of pyruvate dehydrogenase complex)
what is lipoic acid attached to?
lysine
what’s unique about lipoic acid?
disulphide group group in the oxidative form that can be reduced to free sulphate groups to accept intermediates
what’s the mobility of NADH
it is completely mobile
what’s the mobility of FADH2
it is a protein bound electron carrier - not very mobile
what’s the advantage of using a protein complex (pyruvate dehydrogenase complex)
all the substrates and intermediates never get a chance to fly away or separate, everything is interconnected
what are the products of the pyruvate dehydrogenase complex (PDH reaction)
2 acetyl Coa
2 NADH
2 CO2
what is acetyl coa a building block for
cholesterol and fatty acids
