Unit 5: signal receptors Flashcards
1
Q
what are the 4 types of receptor signaling
A
- GPCR, g-protein couple receptors
- tyrosine kinase receptor
- ligand-gated channels
- intracellular receptors (nuclear receptors )
2
Q
GPCR, g-protein couple receptors has 4 main points/ideas
A
- 7 transmembrane domain protein
- uses GTP and G-proteins
- GDP=off GTP = on
- g alpha is a ticking time bomb
3
Q
GPCR, g-protein couple receptors 6 steps to activate and 2 steps to turn off
A
- ligand binds
- conformational shift
- g-protein binds GPCR
- GTP replaces GDP
- g-protein alpha has conformational shift
- g-protein separates and activates other proteins
- g-protein alpha turns GTP into GDP
- ligand falls off GPCR and conformational shift
4
Q
tyrosine kinase receptor has 2 main points/main idea
A
- can’t activate itself
2. uses ATP, kinase and Phosphatase
5
Q
tyrosine kinase receptor 3 steps to activate and 2 steps to turn off
A
- ligand binds 1st receptor
- ligand binds 2nd receptor
- phosphorylate the others tyrosines
- phosphatase removes phosphates
- ligand falls off
6
Q
what is a ligand
A
signal from a cell
7
Q
what is a gate
A
lock on a channel
8
Q
what is a channel
A
tube through membrane to get ions through
9
Q
ligand-gated channels 3 steps to activate 3 steps turn off
A
- ligand binds receptor
- conformational shift and channel opens
- facilitated diffusion of ions
- ligand falls off
- confirmational shift and channel closes
- restore the ion gradient
10
Q
intracellular receptors 2 main idea
A
- inside cell
2. change DNA expression DNA –> RNA –> Protein
11
Q
intracellular receptors 6 steps to activate and 2 steps to turn off
A
- ligand diffuses into the cell
- ligand binds receptor
- conformational shift of receptor
- ligand/receptor complex enters nucleus
- ligand/receptor complex binds DNA
- DNA expression changes DNA –> RNA –> Protein
- ligand falls off and conformational shift
- receptor kicked out of nucleus
