Uncouplers & ETC Inhibitors Flashcards
What happens in cyanide poisioning?
Complex 4 get sinhibited resulting in a backup. NADH holds onto the electrons thus it cannot go through all the complexes. Glycosis or fermentation can’t occur.
Coupled reaction between electrons is falling and pumping fo H+
What happens to the proton motive force?
decreases due to H+ pumping halts
What happens to NADH utilization?
Decreasing, because NADH is stuck w/ electrons
Why wouldn’t increasing NADH would not help with NADH utilization?
they would be stuck as well
What would happen to ATP synthesis?
decreases, H+ cannot power and everything would stop
if complex I was inhibited would it cause less or more of an impact if complex 4 was inhibited?
Less because FADH2 would still go one and some ATP will be produced
What do uncouplers do to H+ pumping?
First it uncouples exergonic electron transport with H+ pumping, creates a channel for H+ to diffuses through
ATP will not be produced
In uncoupling reactions what would happen to the proton motive force?
it goes away
How would the cell respond to the uncoupling?
cell would try to increase NADH utilization and proton pumping to compensate for the loss of H+ but it wouldn’t work
How would the loss of energy through uncoupling help the body?
produces heat- regulates temperature
