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Pass Naplex Now Book II > Ulcerative Colitis & Cronh's D > Flashcards

Ulcerative Colitis & Cronh's D Flashcards

1
Q
  • Ulcerative colitis (UC): is an inflammatory disease of the large intestine. Ulcers form in the inner lining, or mucosa of the colon or rectum often resulting in diarrhea, blood, and pus
  • Crohn’s Disease (CD): is an inflammatory that extended into the deeper layer of the intestinal wall. It’s most often in the ileum and the cecum
  • Suggested tx algorithm
A
  • Start with mesalamine => corticosteroid => immune suppressant
  • Allergy to mesalamine, start with corticosteroid
  • If allergy to sulfa, do not use sulfasalazine
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2
Q

Lialda

  • Administration instruction
  • Special about this tab
  • —- for all 5-ASA—-
  • C/I
  • SEs
  • Urine color:
A

Mesalamine (5-ASA) DR

  • Dose: 2-4 tabs QD w/ FOOD. Do not crush or chew.
  • Tab is coated with a pH dependent polymer film, which breaks down at or above pH 6.8
  • Similar to ASA. Avoid in salicylate sensitivity
  • SEs: HA, abdominal pain, fever, rash
  • Discolor of urine yellow-brown
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3
Q

Asacol HD

  • Dose/frequency
A

Mesalamine High Dose

  • DR: 800 - 1600mg TID. Swallow whole tab
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4
Q

Delzicol

  • Direction to take
A

Mesalamine DR

  • Take on EMPTY stomach: 1H b/4 meal or 2H after
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5
Q

Pentasa

  • Dose
A

Mesalamine CR

  • Dose: 1g QID
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6
Q

Canasa

  • Dose
A

Mesalamine rectal suppository

  • Dose: 1000mg QHS. Retain for 1-3hrs to achieve max benefit.
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7
Q

Rowasa

  • Dose
  • Counseling point regarding suppository
A

Mesalamine rectal suspension enema

  • Take 4g/60mL QHS. Retain over night ~ 8H

Counseling:
- Pt must use promptly once foil wrap is removed. If contents darken (dark brown), discard

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8
Q

Colazal

  • Frequency
  • Prodrug
  • CI
A

Balsalazide

  • Giazo: UC in males (three 1.1g tab BID x 8wks
  • Balsalazide cleaved in the colon to produce mesalamine.
  • Frequency: TID
  • CI: salicylate allergy
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9
Q

Azulfidine

  • C/I
  • SE
  • Monitor
  • Body fluid
  • Indication
A

Sulfasalazine (DMARD)

  • C/I: sulfa and aspirin allergy
  • SEs: HA, skin rash, hepatitis, kidney inflammation, infertility, impaired folate absorption, BMS
  • Monitor: LTF, CBC, CNS
  • Body fluid: turn orange yellow
  • I: UC, RA
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10
Q

Uceris

  • Indication
  • Frequency
A

Budesonide

  • Indication: UC
  • Frequency: QD AM
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11
Q

Medrol

  • Dose
A

Methylprednisolone

  • Dose: 35-40mg/day PO QAM
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12
Q

Cortef

  • Dose
A

Hydrocortisone

  • 200-300 mg/d PO QAM
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13
Q

Cortenema

A

Hydrocortisone enema

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14
Q

Cortifoam

A

Hydrocortisone acetate rectal foam

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15
Q

Sandimmune

  • Indication
A

Cyclosporine

  • Indication: UC when refractory to corticosteroid (off-label), psoriasis, rheumatoid arthritis, solid organ transplant, GVHD,
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16
Q

Remicade

  • Class
  • Frequency
  • Indication
A

Infliximab

  • Class: TNF-blocker
  • Frequency: Start at 0, 2, 6 week then Q8W
    Indication:
  • UC that refractory to corticosteroid
  • Crohn disease
  • Ankylosing spondylitis
  • Psoriatic arthritis
  • Rheumatoid arthritis
17
Q

Humira

  • Class
  • Frequency
  • Indication
A

Adalimumab SQ

  • Class: TNF-blocer
  • Frequency: Q2W

Indication:

  • Ankylosing spondylitis
  • Crohn Disease/UC
  • Juvenile idiopathic arthritis
  • Plaque psoriasis
  • Psoriasis arthritis
18
Q

Cimzia

  • Class
  • Frequency
  • Indication
A

Certrolizumab SQ

  • Class: TNF-blocer
  • Frequency: Q4W
    Indication:
  • Ankylosing spondylitis
  • Crohn Disease
  • UC
  • Psoriatic arthritis
  • Rheumatoid arthritis
19
Q

Simponi

  • Class
  • Indication
A

Golimumab

  • Class: TNF-blocer

Indication:

  • UC
  • Ankylosing spondylitis
  • Psoriatic arthritis
  • Rheumatoid arthritis
20
Q

Imuran

  • Indication
A

Azathioprine

Indication

  • Renal transplant
  • Rheumatoid arthritis
  • UC (off label)
21
Q

Purinethol
Purixan

  • Indication
A

6-Mercaptopurine

Indication

  • UC (off label)
  • Crohn’s Disease
  • ALL/APL (P = promyelocytic)
22
Q

Entocort

  • Indication
A

Budesonide

  • Indication: Crohn’s Disease
23
Q

Dipentum

A

Olsalazine

24
Q

Apriso

  • Frequency
A

Mesalamine

  • PO QD AM
25
Q

Giazo

  • Indication
  • Frequency
  • C/I
A

Balsalazine

  • I: UC in man
  • Frequency: BID
  • C/I aspirin allergy
26
Q

Solu-Medrol

  • Form
A

Methyprednisolone

  • IV 40mg QD
27
Q

Entyvio

  • Indication
  • Form
A

Vedolizumab

  • I: Crohn’s D and UC
  • Form: IV

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