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Pass Naplex Now Book II > HIV - Brand/Generic > Flashcards

HIV - Brand/Generic Flashcards

1
Q

Protease Inhibitors

  • MOA
  • Take w/:
  • Excrete:
  • Sulfa allergy
A
  • Protease enzyme breaks down the protein into function units to be used for final assembly of new virus. Protease inhibitors inhibit this enzyme
  • All take w/ food except Indinavir and Fosamprenavir suspension
  • All excrete the LIVER
  • Sulfa allergy: fosamprenavir, darunavir, tiprinavir
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2
Q

AgenerASE

A

AMprenavir

=> Cha Am dan dan bi erASE ddi

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3
Q

CRIXivan

  • SE
A

INDInavir

  • Kidney stone (Nephrolithiasis) => take w/ plenty of wate
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4
Q

Kaletra

Storage

  • Suspensions
  • Cap
A

Lopinavir-Ritonavir

  • Susp Sol’n => take w/ FOOD; REFRIGERATION b/c it contains EtOH
  • Film coated capsule: do not refrigerate
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5
Q

Viracept

A

Nelfinavir

  • Bad diarrhea
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6
Q

NORvir

  • Storage
  • SEs
A

RITonavir

Storage:

  • Cap: refrigerate
  • Tab/Sol: RT

SE
- Has bad GI, paresthesias

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7
Q

Invirase

A

SaQUINavir

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8
Q

Aptivus

  • SEs
  • BBW
A

TIPranavir

  • Has EtOH

SE

  • Fatal hepatotoxicity
  • Sulfa allergy

BBW: intracranial hemorrhage

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9
Q

Lexiva

A

FoSAMprenavir

  • Sulfa allergy
  • Suspension take on empty stomach
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10
Q

ReyaTAZ

  • SEs
A

ATAZanavir

  • Doesn’t increase lipid
  • Take QD

SEs

  • Cardiac abnormalities
  • Most DDI
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11
Q

Prezista

  • SEs
  • Direction to take
A

DaRUNavir

  • Sulfa allergy
  • Take BID with FOODs and ritonavir
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12
Q

Nucleoside Reverse Transcriptase Inhibitors (NRTI’s)

  • SE
A
  • Inhibits reverse transcriptase from convert RNA to DNA (Proviral DNA)
  • Lactic acidosis
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13
Q

Zerit

A

STAvudine

- SEs: 
   GI intolerance
   Pancreatitis 
   Peripheral neuropathy
   Lactic acidosis 
   Lipodystrophy
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14
Q

EPivir

A

LAMivudine

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15
Q

Retrovir

A

ZiDOvudine

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16
Q

Videx

  • Direction to take
  • SEs
A

DiDANosine

  • Take on empty stomach
  • SEs: Pancreatitis, peripheral neuropathy, retinal pigmentation, and lactic acidosis
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17
Q

Ziagen

A

Abacavir

  • SEs: Hypersensitivity rx HLA B*5701. D/c and do not re-challenge
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18
Q

Viread

  • SEs
A

Tenofovir

  • SEs: lactic acidosis, hepatotoxicity.
    Acute renal failure/Fanconi syndrome
    Osteoporosis
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19
Q

EMTRIva

A

EMTRIcitabine

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20
Q

Integrase inhibitors

- MOA

A
  • Inhibit HIV DNA integrate into host cell DNA
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21
Q

Insentress

  • MOA
A

Raltegravir

  • MOA: Inhibit HIV DNA integrate into host cell DNA
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22
Q

Tivicay

  • MOA
  • Age
  • SEs
A

Dolutegravir

  • MOA: Inhibit HIV DNA integrate into host cell DNA
  • Age: for pt > 12 y.o
  • SEs: HA, insomnia
23
Q

Entry Inhibitors

- MOA

A
  • Inhibit HIV binding and fusion therefore HIV can’t get inside celly
24
Q

Fuzeon

  • MOA
  • SEs
A

Enfuvirtide

  • MOA: Target the gp120 or gp41 proteins on HIV’s surface
  • SE: may cause infection
25
Q

Selzentry

  • MOA
  • Rec dose
    • Take with inhibitors
    • No inhibitors/inducers
    • Take with inducers
  • SEs
A

MAraviroc

  • Is CCR5 (Chemokine receptor type 5) blocker & antagonist
  • CCR5: is a protein which HIV uses to enter its target cells
    • Rec initial dose is 150mg BID if also on inhibitors
    • Rec dose is 300mg BID
    • Rec initial dose 600mg BID if also on inducers
  • SE: hepatotoxicity, heart problem, orthostatic hypoTN
26
Q

Non- Nucleoside Reverse Transcriptase Inhibitors (NNRTI’s)

- MOA

A
  • Inhibits reverse transcriptase from convert RNA to DNA (Proviral DNA)
27
Q

Viramune

A

NeVIRApine - ne VYE ra peen

28
Q

Intelence

  • SEs
A

ETRAvirine - et tra VIR reen

  • SEs: severe skin RASH
29
Q

Rescriptor

  • SEs
A

Delavirdine

  • SE
    Rash, hepatotoxicity (least)
30
Q

SUstiva

  • SEs
  • Preg Cat
  • Direction to take:
A

EFAvirenz

  • SEs: CNS sx: vivid dream, hallucination, false cannabinoid test
  • Preg Cat D
  • Take on empty stomach
31
Q

Eduran

  • SEs
A

Rilpivirine - Ril pi VIR reen

  • SEs: depression, insomnia
32
Q

Glycoproteins gp41

- Function

A
  • Helps to initiate the process of membrane fusion b/w virus and cell
33
Q

Combivir

=> Come LZ

A

Zidovudine + Lamivudine

34
Q

EPizicom

=> EP co Lam

A

Abacavir + Lamivudine

35
Q

TriZivir

LAZ = Trinity last

A

Zidovudine + Lamivudine + Abavavir

36
Q

Truvada

  • Combo
  • Indication

=> TE

A
  • Tenofovir + Emtricitabine

Indication
- FDA approved for PREVENTION of HIV infection in adults 1 tab PO QD

37
Q

Atripla

  • Gold standard
  • Never give to
  • Take w/ ?
A

Efavirenz + Emtricitabine + Tenofovir

  • Never give to preg woman
  • Take QD on Empty stomach
38
Q

CompleRa

  • Take with
A
  • Emtricitabine + Tenofovir + Rilpivirine

- Take with FOOD 1 tab QD

39
Q

Stribild: (TEEC)

  • Take w/
  • CrCl
A
  • Elvitegravir + cobicistat + emtricitabine + tenofovir disoproxil fumarate
  • Take with FOOD 1 tab QD
  • CrCl
40
Q

Fxn of Cobicistat

A
  • Enhancer to prolong the effect of Elvitegravir + emtricitabine + tenofovir
41
Q

Vitravene

  • How to give
  • Indication
A

Fomivirsen

  • A shot directly into the disease eye x 2 separate by 2W
  • Approved for CMV who have failed other therapy
42
Q

Rebetol, Copegus

  • Indication
  • SEs
  • Preg Cat
A

Ribavirin

  • Indication: Hepatitis C use in combo with interferon
  • SEs/CI: Sig heart disease
  • Preg Cat X
43
Q

Pegylated Interferon

  • Brand
  • SEs
A

Pegasys; PEG-Intron

  • Depression & suicidal behavior
44
Q

Egrifta

  • MOA
  • Indication
  • Dosage
  • CI
A

Tesamorelin Injection

  • MOA: growth hormone releasing factor analog

Indication
- Reduces excess abdominal fat in HIV-infected patients with lipodystrophy

Dosage:
- 2mg SC QD

CI

  • Pregnant
  • Active malignancies
45
Q

Fulyzaq

  • Indication
A

Crofelemer

  • Indication: Anti-diarrha for symptomatic relief of non-infectious diarrhea in pts with AIDs/HIV on anti-retrovial therapy
46
Q

Dapsone

  • Indication
A

Sulfadiazine

  • CMV ppx
47
Q

Daraprim

  • Indication
  • MOA
A

Pyrimethamine

  • Indication: antimalaria
  • Use in combination with leucovorin + sulfadiazine for toxoplasmosis treatment
  • MOA: inhibits parasitic dihydrofolate reductase
48
Q

Foscarvir

A

Foscarnet

  • CMV
  • SEs: Nephrotoxic, seizure
49
Q

Cytovene

  • Direction to take it
A

Ganciclovir

  • Take with FOOD
50
Q

Vistide

A

Cidofovir

  • CMV
  • SE: severe nephrotoxicity = must taken with probenecid to help prevent kidney damage
51
Q

Valcyte

A

Ganciclovir

  • CMV
52
Q

Vitrasert

A

Ganciclovir implants

53
Q

Vitravence

A

Fomiversen

  • Shot directly into the eye x 2 separate by 2wks
54
Q

Triumeq

A

Abacavir + Lamiviudine + Dolutegravir

Pass Naplex Now Book II (39 decks)

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