Multiple Sclerosis Flashcards
1
Q
MS is an autoimmune disease in which the body’s immune system attacks the CNS. It affects the ability of nerve cells in the brain and spinal cord to communicate with each other by attacks myelin sheath
- Manage acute attack
A
Acute attack
- Corticosteroid to reduce inflammation
IV methylprednisone with catheter insert in the arm and left it there for 3-5 days. Then pt will be taper with prednisone.
2
Q
Ampyra
- Indication
- Dose
- SEs
- Available through specialty pharmacy.
A
Dalfampridine
- Indication: relapsing MS
- Dose: 10mg PO BID
- SEs: SZ
- Available through specialty phram
3
Q
Gilenya
- Indication
- MOA
- Dose
- SE/Serious SEs
A
Fingolmod
- Indication: relapsing MS
- MOA: a sphingosine 1-phosphate receptor modulator
- Dose: 0.5mg PO QD
Should observe x 6H of 1st dose for s/s of bradycardia
SEs
- HA, flu, diarrhea, back pain, abn LTF, cough
Serious SEs
- Bradycardia
- Infection
- Vision/Breathing/Liver problem
4
Q
Capaxone
- Indication
- Dose
A
Glatiramer
- Indication: MS
- Dose: 20mg SC QD
5
Q
Avonex
- Indication
- Dose
Avonex - Interferon monitoring
- Interferon SEs
A
Interferone Beta 1A
- Indication: MS
- Dose: Avonex: 30mg IM QW
- Prefilled syringe. Refrigerate. RT x 7d. Protect from light
- Vials: refrigerate. RM x 30d. Protect from light
Interferone monitoring
- CBC w/ diff
- Depression/suicidal
- Thyroid
- S/S of CV
- LFTs (Rebif)
- Seizures
Interferon SEs
- Flu like sx: fever, night sweats, muscle ache
6
Q
Betaseron
Extavia
- Dose
- Storage
A
Interferone Beta 1B
- Dose: SC QOD
- RT until reconstitute, then refrigerate and use w/in 3Hs
7
Q
Tysabri
- Indication
- MOA
- SE
- Special program
A
Natalizumab
- Indication: MS and Crohn’s Disease
- MOA: monoclonal antibody
- SEs: serious brain infection
- Program: Pts, prescribers and pharmacies must be enrolled in the Tysabri Outreach Unified Commitment to Health (TOUCH).
8
Q
Rebif
A
Interferone beta 1A
- F: SC 3x/W
- Refrigerate. RT x 30d. Protect from light
9
Q
Techfidera
- Form
- Indication
A
Dimethyl fumarate
- F: PO
- I: Relapse MS
10
Q
Lemtrada
- Form
- Indication
A
Alemtuzumab
- F: IV
- I: Relapse MS
