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Pass Naplex Now Book II > Schizophrenia Brand/Generics > Flashcards

Schizophrenia Brand/Generics Flashcards

1
Q

*Thorazine

A

Chlorpromazine

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2
Q

Thioridazine

A

Mellaril

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3
Q

Mesoridazine

A

Serentil

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4
Q

*Loxitane

  • Indication
  • Administration
A

*Loxapine

  • Indication: acute agitation ass w/ scz or bipolar I disorder
  • Adm by a healthcare professional 10mg PO inhalation using a inhaler
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5
Q

Molindone

A

Moban

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6
Q

Perpenazine

A

Trilafon

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7
Q

Trifluoperazine

A

Stelazine

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8
Q

Thiothixene

A

Navane

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9
Q

*Prolixin

A

Fluphenazine

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10
Q
  • Haldol

- Major SEs

A

Haloperidol

  • QT Prolongation, Tordades de pointes
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11
Q
  • ORAP

- Indication

A

PIMozide

  • Indication: used for Tourette’s only
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12
Q

SEs of these drugs

Anticholinergic SEs

Extrapyramidal SEs

  • Causes:
  • S/S
  • Agents have higher risk
  • Agents have lowest risk

Tardive dyskinesia
- Cause

Neuroleptic malignant syndrome

  • S/S
  • Cause
  • Management
A

SEs: WASH MEN

  • Weight gain: block histamine H1 receptor
  • Anticholinergic: block cholinergic receptor
  • Sedation: Block histamine
  • Hypotension: block alpha-adrenergic
  • Movement disorder - Tardive dyskinesia
  • EPSE
  • Neuroleptic Malignant Syndrome (NMS)

Anticholindergic SEs => Anti- SLUDGE

  • Salivation
  • Lacrimation
  • Urination
  • Defecation
  • GI motility
  • Excretion

Extrapyramidal SEs
- Causes: due to dopamine antagonist activity
- S/S
Dystonia: hrs - day: painful muscle spasm laryngospasm
IV diphenhydramine 25-50mg
Akathisia: days to weeks. Restlessness
Propanolol 30-100 mg QD
Pseudoparkinsonism: weeks to mo
Decrease Ach or Inc dopamine. Benztropine,
Trihexyphenidyl, diphenhydramine, amantadine

Tardive Dyskinesia
- Cause: hypersensitivity rxn due to prolonged blockade of dopamine. Tongue, lip, jaw, face, and extremity movement

Neuroleptic Malignant syndrome
- S/S: rigidity, fever, diaphoresis, altered consciousness, incr BP, increased HR
- Cause: due to depletion of DA in CNS = disruption of muscle contraction, disruption of thermostat system
- Management
D/C drug
Supportive therapy: IV fluid, cooling
Increase DA by DA agonist (bromocriptine)
Dantrolene: muscle relaxant tx of malignant hyperthermia

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13
Q

Agents for rapid transquilization given IM

HAZO

A
  • Haloperidol: 5-10mg IM Q1H prn
  • Aripiprazole 7.5mg/mL repeat in 2H max 30mg/d
  • Ziprasidone 10-20mg IM. Max 40
  • Olanzapine 2.5-10mg IM. May repeat in 2H. Max 30mg/d
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14
Q

Deconate agents

  • Halol
  • Fluphenazine
  • Resperdal
  • Paliperidone
  • Ability maintain
  • Zyprexa Relprevv
A
  • Halol 10-15x PO given monthly
  • Fluphenazine Q2W
  • Risperdal Consta: > 18 y.o given by 25mg (max 50) deep IM Q2W
    Give PO x 3wks then stop PO
  • Paliperidone Palmitate
    Give 234mg on day 1, then 156mg on week later.
    MD given 117 IM injection once a month
  • Ability maintena IM depot QM
  • Zyprexa relprevv (olanzepine ER)
    150mg to 300mg Q2W or
    405 mg Q4W
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15
Q

Clozaril

  • MOA
  • Indication
  • Dose
  • Benefits
  • SEs
A

Clozapine:

=» Must register in Clonazril National Register (CNR)

  • MOA: block D4, 5HT2, alpha, histamine
  • Indication: Szc (treatment resistant)
  • Dose: 300-900mg/day
  • Benefits: doesn’t cause EPS or TD or prolactin level
  • SEs:
    Agranulocytosis: WBC > 3.5K, ANC > 2k
    Hypersalivation and sweating
    SZ
    Hyperglycemia/lipidemia
    Wt gain
    Sedation
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16
Q

Resperdal
Resperdal consta

  • Indication
  • Forms
  • Disadvantage
A

Risperidone

  • Consta: IM inj Q2W => Give 1st dose of oral dosage form. Continue for 3wks then d/c oral
  • Indication: scz, bipolar mania, autism
  • Forms: Tab, disintergrating tabs, sol’n, IM inj (consta)
  • SEs: higher risk of EPS
17
Q

Zyprexa
Zyprexa Relprevv
Zydis = ODT

- Zyprexa Relprevv dose
  Warning, registration
- Indication
- SEs
- Monitor
- Zydis counseling ODT
A

Olanzapine
- Atypical

Zyprexa Relprevv:

  • ER => give 150-300mg PO Q2W or 405mg Q4W
  • Can cause post injection delirium/sedation
  • Must register in ZYPREXA RELPREVV pt care program
  • Indication: Scz, bipolar, depression, depression resistant use with fluoxetine
  • SEs: Wt gain and DM, hyperG/lipidemia
  • Monitor: wt, glucose, lipids, orthostatic hypoTN (IM)

Zydis counseling ODT

  • Must keep tablet in blister pack until ready to take
  • Open the package n peel back the foil from the tablet blister
  • Do not push a tablet through the foil; you may damage the tablet
  • Using dry hands, remove the tablet - place it in your mouth. It will begin to dissolve right away
  • Do not swallow the tablet whole. Allow it to dissolve in your mouth without chewing
  • Swallow several times. If desire, pt may drink liquid to help swallow the dissolve tablet
18
Q

Seroquel

  • Indication
  • Dose
  • Benefit
A

Quetiapine

  • Indication: Scz, bipolar, major depression
  • Dose: 100-800mg/d HS empty stomach
  • Benefit: lowest anticholinergic of all atypical
19
Q

Geodon

  • Indication
  • Dose
  • Benefits
  • Disadvantage
A

Ziprasidone

  • Indications: Scz, bipolar
  • Dose: start 20mg PO BID with Food. Max 80mg BID
  • Benefit: least weight gain and DM
  • SEs: Prolong QT
20
Q

Abilify
Ability Maintena

  • Indication
  • Dose
  • Adv
A

Aripiprazole

  • Abilify DISMELT: contain phenylalamine
  • Ability Maintena: QM injection
  • Indication: Scz, bipolar, depression, autism
  • Dose 10-15mg QD. Max 30mg
    Maintena: 400mg IM QM
  • Adv:
    Long elimination half life
    Low risk of wt gain
    No cardiac effects
    Relatively low risk EPS
21
Q

InVEGA

  • Indication
  • Dose
  • Paliperidone palmitate
  • SEs
A

PaLIPerdone

  • Indication: scz
  • Dose: 3-12 mg PO QD
    => Drug delivers over 24H using innovative OROS
  • Paliperidone Palmitate Inj: 117 mg QM
    => Start 234mg on D1 then 156 mg 1W later
  • SEs: QT prolong
22
Q

Fanapt

  • Indication
  • Dose
  • SE
A

ILoperidone

  • Indication: scz
  • Dose: start 1mg BID. Target 6-12mg BID due to
  • Orthostatic hypoTN
23
Q

Saphris

  • Form
  • Indication
  • MOA
  • Dose
    Direction to take
  • SEs
A

Asenapine

  • Sublingual only. Swallow = not working
  • Indication: scz, bipolar
  • MOA: serotonin, adrengergic alpha, dopamine, and histamine
  • Dose:
    Scz: 5mg SL BID. Do not drink or eat for 10min after arm
    Bipolar: 5-10mg BID
  • SEs: serious allergic rxn
    Do not use in pt w/ dementia-related psychosis = death
24
Q

Latuda

A

Lurasidone

  • Indication: scz
  • Dose: 40-80mg QD with FOOD
  • SEs: neutropenia, leukopenia
25
Q
  • Highest wt gain
  • No wt gain, DM, dyslipidemia
  • No QT
  • Agents for depression
  • Agents from bipolar
  • Agents for autism
A

Wt gain
- Clozapin n olanzepine
No wt gain
- Ziprassidone, aripiprazole, paliperidone, asenapine

No QT = AI LO
- Saphris, abilify, latuda, zyprexa

Depression
- Abilify, seroquel, zyprexa

Bipolar
- Resperidone, geodon, ability, seroquel, saphris, zyprexa

Autism
- abilify and resperdone

26
Q

Dantrium

  • Indication
A

Dantrolene

  • Muscle relaxant tx of malignant hyperthermia
27
Q

Adusuve

  • Class
A

Loxapine

  • Typical
28
Q

FazaClo

A

Clozapine

  • Form: ODT
  • I: SZP resistant
29
Q

Versacloz

  • Form
  • Expiration
  • Indication
A

Clozapine

  • Form: Yellow suspension. Protect from light. Shake 10s b/4 use.
  • Exp 100 days after bottle is opened
  • I: SZP resistant

Pass Naplex Now Book II (39 decks)

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