Alzheimer's Disease Flashcards
1
Q
Aricept
- MOA
- Indication
- Form
- Dose
- Indication:
- SEs for all cholinesterase
A
Donepezil
- MOA: Cholinergic => inc Ach
- Indication: Alzheimer’s D
- Form: Tab and ODT
- Dose: start 5mg QHS => 10 => 23mg QHS
- Indication: AZ
SEs
- Increase gastric secretion (PUD)
- N/V
- Cholinergic SEs: SLUGE
- Bradycardia
- May worsen asthma/COPD
2
Q
Exelon
- MOA
- Indication
- Dose
- Form
- SE
A
Rivastigmine
- MOA: Cholinergic => Increase Ach
- Indication: Alzheimer’s Disease
- Dose: Start 1.5mg PO BID with FOOD
Patch: Once daily - Form: Tab, patch
- SE: N/V. Patch causes less N/V b/c drug levels are lower and steadier than with oral Exelon
3
Q
Razadyne
- MOA
- Indication
- Dose
- Caution
A
Galantamine
- MOA: Cholinergic => Increase Ach
- Indication: Alzheimer’s Disease
- Dose: IR 4mg BID; ER 8mg QD with AM meal to decr N/V
- Caution: hypersensitivity to daffodil bulbs
4
Q
Namenda
- MOA
- Dose
- SEs
A
Memantine
- MOA: NMDA receptor antagonist. The drug shields the brain from overexposure to glutamate. Glutamate contributes to the death of brain cells in pts w/ AD
- Dose: start 5mg QD => 10mg BID
- SEs: dizziness, confusion, constipation, HA, rash
5
Q
Amyvid
- Use
A
Florbetapir F18
- Radioactive diagnostic agent that binds to beta-amyloid aggregates, and is intended for use with PET imaging of the brain for patients being evaluated for AD
6
Q
Urecholine
- MOA/Class
- Indication
A
Bethanechol
- MOA: Cholinesterase inhibitors => incr Ach
- Indication: Urinary Retention
7
Q
Evoxac
- MOA/Class
- Indication
A
Cevimeline
- MOA: Cholinesterase inhibitors => incr Ach
- Indication: Sjogren’s syndrome: tx of dry mouth
8
Q
Prostigmin
A
Neostigmine
- MOA: Cholinesterase inhibitors => incr Ach
- Indication: Myasthenia Gravis
9
Q
Physostigmine
- MOA
- Indication
A
- MOA: Cholinesterase inhibitors => incr Ach
- Indication: Myasthenia Gravis
