Erectile Dysfunction (ED) Flashcards
1
Q
Revatio
Viagra
- MOA
- C/I
- ADEs
- Dose/Indication
- DDI
A
Sildenafil
- MOA: PDE5 inhibitors => inc cGMP => incr SM relaxation and inflow of blood into the corpus cavernous.
- C/I: nitrate use (severe hypoTN)
- ADEs: HA, flushing, visual disturbances, insomnia, diarrhea
Dose/Indication
- ED (Viagra): 25-100 mg PO 1H prior to intercourse
- Pulm HTN (Revatio): 20 mg PO TID
DDI
- Caution w/ alpha blockers
- CYP3A4 substrate
2
Q
Adcirca
Cialis
- MOA
- Indication/Dose
- DDI
A
Tadalafil
- MOA/SEs: similar to sildenafil
Indication/Dose
- ED: 10mg 30min prior to intercourse. Work up to 36H
- BPH: 5mg PO QD
- Pulm HTN: 40mg PO QD
DDI:
- Avoid nitrate. Give 48H after last dose
- Caution with alpha-blocker: hypoTN
- 3A4 substrate
3
Q
Levitra
- MOA/SEs
- Indication
- Dose
- DDI
- Other SEs
A
Vardenafil
- MOA/SEs: similar to viagra
- Indication: ED
- Dose: 10mg 1H prior to intercourse
DDI
- Ritonavir
- Alpha-blocker
- CI with nitrates for 72H
Other SEs
- Sudden hearing loss
- Sz
4
Q
Stendra
- MOA/SEs
- Dose
- DDI
A
Avanafil
- MOA/SEs: similar viagra
- Dose: 50-200mg ~30 prior to intercourse
DDI:
- CYP3A4 inhibitor
- Alpha blocker
5
Q
MUSE
- MOA
- How to administer
- Storage
A
Alprostadil
- MOA: widening blood vessels, inc blood flow to the penis and help cause an erection
- MUSE = transurthral therapy. Small pellet that is inserted into the urethra with an applicator. When press the button on the applicator, u release the pellet. It absorbed and an erection develops in ~10 min and last ~30min. Do not use more than 2x in 24H.
- Store in fridge
6
Q
Staxyn
- Form
A
Vardenafil
- Form: ODT 10mg
7
Q
Caverject
A
Alprostadil
- Caverject: Inject into the spongy tissue to the penus (corpus cavernosum). Not to be used more than 3x/wk.
8
Q
Caverject impulse
- Storage
A
Alprostadil
- Store: unreconstituted at RT
9
Q
Caverject sterile powder
- Storage
A
Alprostadil
- Store: fridge
10
Q
Caverject solution
- Storage
A
Alprostadil
- Store in FREEZER
