Tumor suppressor genes (Pg. 218) - C Flashcards
Product / Ass
TSG - APC (Product/Ass)
Product: Negative regulator of β-catenin/WNT pathway
Ass: Colorectal cancer (associated with FAP)
Product / Ass
TSG - BRCA1/BRCA2 (Product/Ass)
Product: DNA repair protein
Ass: Breast, ovarian, and pancreatic cancer
Product / Ass
TSG - CDKN2A (Product/Ass)
Product: p16, blocks G1 S phase
Ass: Melanoma, pancreatic cancer
Product / Ass
TSG - DCC (Product/Ass)
Product: DCC (“Deleted in Colon Cancer)
Ass: Colon cancer
Product / Ass
TSG - DPC4/SMAD4 (Product/Ass)
Product: DPC—Deleted in Pancreatic Cancer
Ass: Pancreatic cancer
Product / Ass
TSG - MEN1 (Product/Ass)
Product: Menin
Ass: MEN 1 (Pituitary, Pancreatic, Parathyroid)
Product / Ass
TSG - NF1 (Product/Ass)
Product: Neurofibromin (Ras GTPase activating protein)
Ass: Neurofibromatosis type 1
Product / Ass
TSG - NF2 (Product/Ass)
Product: Merlin (schwannomin) protein
Ass: Neurofibromatosis type 2
Product / Ass
TSG - PTEN
Product: Tyrosine phosphatase of PIP3 (eg, protein kinase B [AKT] activation)
Ass: Breast cancer, prostate cancer, endometrial cancer
Product / Ass
TSG - Rb
Product: Inhibits E2F; blocks G1–>S phase
Ass: Retinoblastoma, osteosarcoma
Product / Ass
TSG - TP53
Product: p53, activates p21, blocks G1–>S phase
Ass: Most human cancers, Li-Fraumeni syndrome (multiple malignancies at early age, aka, SBLA cancer syndrome: Sarcoma, Breast, Leukemia, Adrenal gland)
Product / Ass
TSG - TSC1
Product: Hamartin protein
Ass: Tuberous sclerosis
Product / Ass
TSG - TSC2
Product: Tuberin protein
Ass: Tuberous sclerosis
Product / Ass
TSG - VHL
Product: Inhibits hypoxia inducible factor 1a
Ass: von Hippel-Lindau disease
Product / Ass
TSG - WT1
Product: Transcription factor that regulates urogenital development
Ass: Wilms tumor (nephroblastoma)
