Autoantibodies (Pg. 111) - C

Question 1

Anti-ACh receptor

Answer 1

Myasthenia gravis

Question 2

Anti-glomerular basement membrane

Answer 2

Goodpasture syndrome

Question 3

Anti-β2 glycoprotein

Answer 3

Antiphospholipid syndrome

Question 4

Anticardiolipin, lupus anticoagulant

Answer 4

SLE, antiphospholipid syndrome

Question 5

Anticentromere

Answer 5

Limited scleroderma (CREST syndrome)

Question 6

Anti-desmoglein (anti-desmosome)

Answer 6

Pemphigus vulgaris

Question 7

Anti-glutamic acid decarboxylase, islet cell cytoplasmic antibodies

Answer 7

Type 1 diabetes mellitus

Question 8

Anti-hemidesmosome

Answer 8

Bullous pemphigoid

Question 9

Antisynthetase (eg, anti-Jo-1), anti-SRP, anti- helicase (anti-Mi-2)

Answer 9

Polymyositis, dermatomyositis

Question 10

Antimicrosomal, antithyroglobulin, anti-thyroid peroxidase

Answer 10

Hashimoto thyroiditis

Question 11

Antimitochondrial

Answer 11

1° biliary cirrhosis

Question 12

Antiparietal cell, anti-intrinsic factor

Answer 12

Pernicious anemia

Question 13

Antiphospholipase A2 receptor

Answer 13

1° membranous nephropathy

Question 14

Anti-Scl-70 (anti-DNA topoisomerase I)

Answer 14

Scleroderma (diffuse)

Question 15

Anti-smooth muscle

Answer 15

Autoimmune hepatitis type 1

Question 16

Anti-SSA, anti-SSB (anti-Ro, anti-La)

Answer 16

Sjögren syndrome

Question 17

Anti-TSH receptor

Answer 17

Graves disease

Question 18

Anti-presynaptic voltage-gated calcium channel

Answer 18

Lambert-Eaton myasthenic syndrome

Question 19

IgA anti-endomysial, IgA anti-tissue transglutaminase

Answer 19

Celiac disease

Question 20

MPO-ANCA/p-ANCA

Answer 20

Microscopic polyangiitis, eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome), ulcerative colitis

Question 21

PR3-ANCA/c-ANCA

Answer 21

Granulomatosis with polyangiitis (Wegener)

Question 22

Rheumatoid factor (IgM antibody against IgG Fc region), anti-CCP (more speci c)

Answer 22

Rheumatoid arthritis

Question 23

Antinuclear (ANA)

Answer 23

Nonspecific screening antibody, often associated with SLE

Question 24

Anti-dsDNA, anti-Smith

Answer 24

SLE

Question 25

Anti-histone

Answer 25

Drug-induced lupus

Question 26

Anti-U1 RNP (ribonucleoprotein)

Answer 26

Mixed connective tissue disease