HLA subtypes ass w/ disease (Pg. 96) - C

Question 1

HLA subtype - A3

Answer 1

Hemochromatosis

Question 2

HLA subtype - B8

Answer 2

Addison disease, myasthenia gravis, Graves

disease

Question 3

HLA subtype - B27

Answer 3

Seronegative arthropathies (PAIR):

• Psoriatic arthritis
• Ankylosing spondylitis
• IBD-associated arthritis
• Reactive arthritis

Question 4

HLA subtype - DQ2/DQ8

Answer 4

“I ate (8) too (2) much gluten at Dairy Queen.”

• Celiac disease

Question 5

HLA subtype - DR2

Answer 5

“Multiple hay pastures have dirt.”

Multiple sclerosis, hay fever, SLE, Goodpasture syndrome

Question 6

HLA subtype - DR3

Answer 6

“DM1, 2/3–>SLE!”

Diabetes mellitus type 1, SLE, Graves disease, Hashimoto thyroiditis, Addison disease

Question 7

HLA subtype - DR4

Answer 7

“4 walls in a “rheum” (room)”

Rheumatoid arthritis, diabetes mellitus type 1, Addison disease

Question 8

HLA subtype - DR5

Answer 8

Pernicious anemia vitamin B12 deficiency, Hashimoto thyroiditis