Teratogens (Pg. 582) - C

Question 1

Teratogen - ACE inh

Answer 1

Renal damage

Question 2

Teratogen - Alkylating agents

Answer 2

Absence of digits, multiple anomalies

Question 3

Teratogen - Aminoglycosides

Answer 3

Ototoxicity

Question 4

Teratogen - Antiepileptic drugs

Answer 4

Neural tube defects, cardiac defects, cleft palate, skeletal abnormalities (eg, phalanx/nail hypoplasia, facial dysmorphism)

Question 5

Teratogen - Diethylstilbestrol

Answer 5

Vaginal clear cell adenocarcinoma, congenital Müllerian anomalies

Question 6

Teratogen - Folate antagonists

Answer 6

Neural tube defects (Includes trimethoprim, methotrexate, antiepileptic drugs.)

Question 7

Teratogen - Isotretinoin

Answer 7

• Multiple severe birth defects

- Contraception mandatory

Question 8

Teratogen - Lithium

Answer 8

Ebstein anomaly (apical displacement of tricuspid valve)

Question 9

Teratogen - Methimazole

Answer 9

Aplasia cutis congenita

Question 10

Teratogen - Tetracyclines

Answer 10

“Teethracyclines.”

• Discolored teeth, inhibited bone growth

Question 11

Teratogen - Thalidomide

Answer 11

Limb defects with “tha-limb-domide.”

• Limb defects (phocomelia, micromelia— “flipper” limbs)

Question 12

Teratogen - Warfarin

Answer 12

Bone deformities, fetal hemorrhage, abortion, ophthalmologic abnormalities

Question 13

Teratogen - Alcohol

Answer 13

Common cause of birth defects and intellectual

disability

Question 14

Teratogen - Cocaine

Answer 14

Low birth weight, preterm birth, IUGR,

placental abruption

Question 15

Teratogen - Smoking

Answer 15

Low birth weight (leading cause in developed
countries), preterm labor, placental problems,
IUGR, SIDS

Question 16

Teratogen - Iodine

Answer 16

Congenital goiter or hypothyroidism (cretinism)

Question 17

Teratogen - Maternal Diabetes

Answer 17

Caudal regression syndrome (anal atresia
to sirenomelia), congenital heart defects,
neural tube defects, macrosomia, neonatal
hypoglycemia

Question 18

Teratogen - Methylmercury

Answer 18

Neurotoxicity

Question 19

Teratogen - Vitamin A

Answer 19

Extremely high risk for spontaneous abortions

and birth defects (cleft palate, cardiac)

Question 20

Teratogen - X-rays

Answer 20

Microcephaly, intellectual disability