Tumor Suppressor Genes

Question 1

Associated tumor(s) with Rb

Answer 1

Retinoblastoma, osteosarcoma

Question 2

Gene product of Rb

Answer 2

Inhibits EF-2, blocks G1 to S phase

Question 3

Associated tumor(s) with p53

Answer 3

Most human cancers, Li-Fraumeni syndrome

Question 4

Gene product of p53

Answer 4

Transcription factor for p21, blocks G1 to S phase

Question 5

Associated tumor(s) with BRCA1

Answer 5

Breast and ovarian cancer

Question 6

Gene product of BRCA1

Answer 6

DNA repair protein

Question 7

Associated tumor(s) with BRCA2

Answer 7

Breast and ovarian cancer

Question 8

Gene product of BRCA2

Answer 8

DNA repair protein

Question 9

Associated tumor(s) with p16

Answer 9

Melanoma

Question 10

Associated tumor(s) with APC

Answer 10

Colorectal cancer (associated with FAP)

Question 11

Associated tumor(s) with WT1

Answer 11

Wilm’s tumor (nephroblastoma)

Question 12

Associated tumor(s) with NF1

Answer 12

Neurofibromatosis type 1

Question 13

Gene product of NF1

Answer 13

RAS GTPase activating protein (RAS-GAP)

Question 14

Associated tumor(s) with NF2

Answer 14

Neurofibromatosis type 2

Question 15

Gene product of NF2

Answer 15

Merlin (schwannomin) protein

Question 16

Associated tumor(s) with DPC4

Answer 16

Pancreatic cancer

Question 17

Associated tumor(s) with DCC

Answer 17

Colon cancer