Important Oncogenes and Associated Cancers Flashcards
Tumor(s) associated with PDGFB
Astrocytoma
Tumor(s) associated with ERBB2 (HER2/neu)
Subset of breast carcinomas
Tumor(s) associated with RET
MEN 2A, MEN 2B, and sporadic medullary carcinoma of thyroid
Tumor(s) associated with KIT
Gastrointestinal stromal tumor
Tumor(s) associated with RAS gene family
Carcinomas, melanoma, and lymphoma
Tumor(s) associated with ABL
CML and some types of ALL
Tumor(s) associated with c-MYC
Burkitt lymphoma
Tumor(s) associated with N-MYC
Neuroblastoma
Tumor(s) associated with L-MYC
Lung carcinoma (small cell)
Tumor(s) associated with CCND1 (cyclin D1)
Mantle cell lymphoma
Tumor(s) associated with CDK4
Melanoma
Gene product of ABL
Tyrosine kinase
Gene product of c-MYC
Transcription factor
Gene product of bcl-2
Anti-apoptotic molecule
Tumor(s) associated with bcl-2
Follicular and undifferentiated lymphomas (inhibits apoptosis)