Important Oncogenes and Associated Cancers Flashcards

1
Q

Tumor(s) associated with PDGFB

A

Astrocytoma

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2
Q

Tumor(s) associated with ERBB2 (HER2/neu)

A

Subset of breast carcinomas

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3
Q

Tumor(s) associated with RET

A

MEN 2A, MEN 2B, and sporadic medullary carcinoma of thyroid

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4
Q

Tumor(s) associated with KIT

A

Gastrointestinal stromal tumor

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5
Q

Tumor(s) associated with RAS gene family

A

Carcinomas, melanoma, and lymphoma

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6
Q

Tumor(s) associated with ABL

A

CML and some types of ALL

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7
Q

Tumor(s) associated with c-MYC

A

Burkitt lymphoma

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8
Q

Tumor(s) associated with N-MYC

A

Neuroblastoma

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9
Q

Tumor(s) associated with L-MYC

A

Lung carcinoma (small cell)

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10
Q

Tumor(s) associated with CCND1 (cyclin D1)

A

Mantle cell lymphoma

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11
Q

Tumor(s) associated with CDK4

A

Melanoma

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12
Q

Gene product of ABL

A

Tyrosine kinase

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13
Q

Gene product of c-MYC

A

Transcription factor

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14
Q

Gene product of bcl-2

A

Anti-apoptotic molecule

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15
Q

Tumor(s) associated with bcl-2

A

Follicular and undifferentiated lymphomas (inhibits apoptosis)

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16
Q

Gene product of HER2/neu (c-erbB2)

A

Tyrosine kinase

17
Q

Gene product of RAS

A

GTPase

18
Q

Gene product of L-myc

A

Transcription factor

19
Q

Gene product of N-myc

A

Transcription factor

20
Q

Gene product of ret

A

Tyrosine kinase

21
Q

Gene product of KIT

A

Cytokine receptor

22
Q

Tumor(s) associated with BRAF

A

Melanoma

23
Q

Gene product of BRAF

A

B-raf