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Board Review > Bacterial Toxin Mechanism of Action > Flashcards

Bacterial Toxin Mechanism of Action Flashcards

1
Q

MOA of Bacillus anthracis (edema factor)

A

PA+EF = increases cAMP

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2
Q

MOA of Bacillus anthracis (lethal factor)

A

PA+LF = zinc dependent protease that cleaves MAP kinase leading to cell death

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3
Q

MOA of Bordetella pertusis toxin

A

Overactivates AC increasing cAMP by disabling Gi, impairing phagocytosis to permit survival

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4
Q

MOA of Clostridium botulinum toxin

A

Cleaves SNARE protein required for NT release, prevents release of ACh

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5
Q

MOA of Clostridium difficile (toxin A, toxin B)

A

A= enterotoxin, binds to brush border of the gut

B= cytotoxin, destroys the cytoskeletal membrane

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6
Q

MOA of Clostridium perfringens (alpha toxin)

A

Phospholipase that degrades tissue and cell membranes

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7
Q

MOA of Clostridium tetani toxin

A

Cleaves SNARE protein required for NT release, prevents release of GABA and glycine

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8
Q

MOA of Corynebacterium diptheriae

A

Inactivates elongation factor 2 (EF-2)

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9
Q

MOA of EHEC

A

Inactivates 60S ribosome by removing adenine from rRNA

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10
Q

MOA of ETEC (heat-labile toxin)

A

Overactivates AC which increases cAMP

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11
Q

MOA of ETEC (heat-stable toxin)

A

Overactivates GC which increases cGMP

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12
Q

MOA of lipopolysaccharide (endotoxin)

A

Produces inflammatory response

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13
Q

MOA of Pseudomonas aeruginosa

A

Inactivates elongation factor 2 (EF-2)

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14
Q

MOA of Shigella species

A

Inactivates 60S ribosome by removing adenine from rRNA

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15
Q

MOA of Staphylococcus aureus (enterotoxin)

A

Stimulates cytokine release and inflammation

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16
Q

MOA of Staphylococcus aureus (exfoliative toxin)

A

Breaks down desmosomes within epidermis

17
Q

MOA of Staphylococcus aureus (TSST-1)

A

Brings MCH-II and TCR in proximity causing release of IFN-gamma and IL-2

18
Q

MOA of Streptoccocus pyogenes (streptolysin O)

A

Protein that degrades cell membrane

19
Q

MOA of Vibrio cholerae toxin

A

Permanently activates Gs, increasing cAMP

Board Review (49 decks)

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