G-protein-linked 2nd Messengers Flashcards
G-protein class and major functions of alpha-1
- Gq
- increases smooth muscle contraction
- increases pupillary dilator muscle contraction (mydriasis)
- increases intestinal and bladder sphincter muscle contraction
G-protein class and major functions of alpha-2
- Gi
- decreases sympathetic outflow
- decreases insulin release
- decreases lipolysis
- increases platelet aggregation
G-protein class and major functions of beta-1
- Gs
- increases heart rate
- increases contractility
- increases renin release
- increases lipolysis
G-protein class and major functions of beta-2
- Gs
- vasodilation
- bronchodilation
- increases heart rate
- increases contractility
- increases lipolysis
- increases insulin release
- decreases uterine tone (tocolysis)
- ciliary muscle relaxation
- increases aqueous humor production
G-protein class and major functions of M1
- Gq
- CNS
- enteric nervous system
G-protein class and major functions of M2
- Gi
- decreases heart rate and contractility of atria
G-protein class and major functions of M3
- Gq
- increases exocrine gland secretions (e.g., lacrimal, gastric acid)
- increases gut peristalsis
- increases bladder contraction
- bronchoconstriction
- increases pupillary sphincter muscle contraction (miosis)
- ciliar muscle contraction (accommodation)
G-protein class and major functions of D1
- Gs
- relaxes renal vascular smooth muscle
G-protein class and major functions of D2
- Gi
- modulates transmitter release, especially in brain
G-protein class and major functions of H1
- Gq
- increases nasal and bronchial mucus production
- contraction of bronchioles
- pruritis and pain
G-protein class and major functions of H2
- Gs
- increases gastric acid secretion
G-protein class and major functions of V1
- Gq
- increases vascular smooth muscle contraction
G-protein class and major functions of V2
- Gs
- increases water permeability and reabsorption in the collecting tubules of the kidney (V2 is found in the 2 kidneys)
