Pysch Drugs Flashcards
Preferred drug(s) for alcohol withdrawal
Benzodiazepines
Preferred drug(s) for anxiety
SSRIs, SNRIs, buspirone
Preferred drug(s) for ADHD
Methylphenidate, amphetamines
Preferred drug(s) for bipolar disorder
“Mood stabilizers” (e.g. lithium, valproic acid, carbamazepine), atypical antipsychotics
Preferred drug(s) for bulimia
SSRIs
Preferred drug(s) for depression
SSRIs, SNRIs, TCAs, buspirone, mirtazapine (especially with insomnia)
Preferred drug(s) for OCD
SSRIs, clomipramine
Preferred drug(s) for panic disorder
SSRIs, venlaxafine, benzodiazepines
Preferred drug(s) for PTSD
SSRIs
Preferred drug(s) for schizophrenia
Antipscyhotics
Preferred drug(s) for social phobias
SSRIs
Preferred drug(s) for Tourette’s
Antipsychotics (e.g. haloperidol, risperidone)
Drugs classified as typical antipsychotics
Haloperidol and the “-azines”
MOA of typical antipsychotics
Block dopamine D2 receptors (increases cAMP)
SE of typical antipsychotics
EPS side effects (dyskinesias), endocrine side effects (galactorrhea)
Side effects arising from blocking muscarinic (dry mouth, constipation), alpha-1 (hypotension), and histamine (sedation) receptors
Symptoms of neuroleptic malignant syndrome caused by typical antipsychotics
Think FEVER
Fever Encephalopathy Vitals unstable Elevated enzymes Rigidity of muscles
Treatment of neuroleptic malignant syndrome
Dantrolene, D2 agonists (bromocriptine)
Symptoms of tardive dyskinesia caused by typical antipsychotics
Stereotypical facial movements as a result of long-term antipsychotic use, often irreversible
Typical antipsychotic that can cause corneal deposits
Chlorpromazine
Typical antipsychotic that can cause retinal deposits
Thioridazine
Drugs classified as atypical antipsychotics
Olanzapine, clozapine, quetiapine, risperidone, aripiprazole, ziprasidone
MOA of atypical antipsychotics
Varied effects on 5-HT2, dopamine, and alpha and H1 receptors
Atypical antipsychotic associated with agranulocytosis and seizures
Clozapine
Atypical antipsychotic associated with prolonged QT interval
Ziprasidone
MOA of buspirone
Stimulates 5-HT1A receptors, takes 1-2 weeks to take effect
Indication of buspirone
Generalized anxiety disorder
Drugs classified as SSRIs
Fluoxetine, paroxetine, sertraline, citalopram
SE of SSRIs
GI distress, sexual dysfunction (anorgasmia and decreased libido)
Serotonin syndrome: with any drug that increases serotonin resulting in hyperthermia, confusion, myoclonus, cardiovascular collapse, flushing, diarrhea, seizures
Treatment of serotonin syndrome
Cyproheptadine (5-HT2 receptor antagonist)
Drugs classified as SNRIs
Venlafaxine, duloxetine
SNRI that can be used to treat diabetic peripheral neuropathy
Duloxetine
SE of SNRIs
Increased BP, sedation, nausea, risk of inducing mania
Drugs classified as TCAs
Amitryptyline, nortriptyline, imipramine, desipramine, clomipramine, doxepin, amoxapine
MOA of TCAs
Block reuptake of NE and serotonin
TCA that can be used to treat bedwetting
Imipramine
TCA that can be used to treat OCD
Clomipramine
SE of TCAs
Postural hypotension, atropine like effects (tachycardia, urinary retention, dry mouth)
Tri-C’s: Convulsions, Coma, Cardiotoxicity
Treatment of TCA cardiovascular toxicity
NaHCO3
Drugs classified as MAOIs
Tranycypromine, phenelzine, isocarboxazid, selegiline (selective MAO-B inhibitor)
MOA of MAO-Is
Nonselective MAO inhibition increases levels of amine neurotransmitters (NE, serotonin, dopamine)
SE of MAO-Is
Hypertensive crisis (most notably with ingestion of tyramine in wines and cheeses), CNS stimulation
MOA of mirtazapine
Alpha-2 antagonist (increases release of NE and serotonin) and potent 5-HT2 and 5-HT3 receptor antagonist
MOA of maprotiline
Blocks NE reuptake
MOA of trazodone
Inhibits serotonin reuptake
SE of trazodone
Sedation, nausea, priapism, postural hypotension
