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Clinical Chemistry > Tumor Markers > Flashcards

Tumor Markers Flashcards

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1
Q

PSA

A

Prostate Cancer

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2
Q

NSE

A

Neuroendocrine Tumors

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3
Q

ALP

A 
Metastatic Bone Carcinoma
HCC
Osteosarcoma
Leukemia
Lymphoma
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4
Q

LDH

A

Hematologic Malignancies

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5
Q

Immunoglobulin

A

Bone Marrow Cancer - MULTIPLE MYELOMA

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6
Q

Calcitonin

A

Medullary Thyroid Carcinoma

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7
Q

HCG

A

PRIMARY: Diagnosis and Management - Gestational Trophoblastic disease (Choriocarcinoma)

SECONDARY: Staging and Monitoring - Germ cell tumors of the testis and ovary

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8
Q

ACTH

A

Small cell carcinoma of the lungs (Ectopic ACTH production)
Non specific - Pancreatic, Gastric, Colon Cancer
Effect: PARA NEOPLASTIC ENDOCRINE SYNDROME

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9
Q

Thyroglobulin

A

Recurrent Thyroid Cancer

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10
Q

AFP

A

Specific - Hepatocellular carcinoma

Increase - Chronic and Acute Hepatitis

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11
Q

CEA

A

Marker: GI Cancer/Colorectal Cancer

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12
Q

CA 125

A

Epithelial Ovarian Cancer

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13
Q

CA 15-3

A

Breast Cancer

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14
Q

CA 19-9

A 
First Id - Human colorectal cancer
Pancreatic cancer (High SENSI and SPECI than CEA)
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15
Q

Estrogen and Progesterone Receptors

A

Breast Cancer

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16
Q

Her2/NEU

A

Breast and Ovarian cancer

GI tumors

17
Q

EGF Receptor

A

Cancer in:
Head
Neck
Ovarian Cervical

18
Q

Beta TGT

A

Diagnosis by measuring extent of inhibition

19
Q

Alpha TGT

A

Epithelial Cell Tumor

20
Q

PDGF

A

Mitogen: Lymphoid, Myeloid, Fibroblasts
Cancer
15%: Lymphomas, Sarcoma, Carcinoma (not specific)
Breast Cancer (directly proportional to cancer staging).

21
Q

Basic Fibroblast Growth factor

A

90% Lung Cancer
60% Lymphomas
50% Cancer CNS

22
Q

EGF

A

Stomach and Tongue Carcinoma

23
Q

NEU/HER2

A 
Breast Cancer (Monitoring, Staging, Diagnosis)
Directly Proportional to p185 ERBB2 ECD
Others:
Pulmonary Lung Cancer
HCC
Adenoma of Colon
Screen Pneumoconiosis
24
Q

Serum p21

A

83% Lung Cancer

39% Pneumoconiosis

25
Q

Mutant p21

A

80% Vinyl chloride induced angio-carcinoma of the Liver

26
Q

p53

A 
30% Lung Cancer, Liver Cirrhosis
20% HCC
8% Breast CA
1:5 in Colon carcinoma
1:10 in Colon Adenoma
27
Q

Anti-p53

A

30% Bladder, Pancreatic, Childhood Lymphoma
25% Lung Cancer and Small cell tumor
15% Ovarian, Colon, Breast CA, Intraductal CA

28
Q

MYC-oncogene-encoded protein

A

20% Breast CA, and Colon Cancer

29
Q

Anti MYC

A

55-65% Colorectal cancer
10% Breast CA, Ovarian CA
Myeloid Leukemia
Burkitt’s Lymphoma

Clinical Chemistry (20 decks)

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