Proteins Flashcards
All proteins are synthesized in the liver, and by hepatocyte, except _____________
Immunoglobulins
Plasma Proteins (Migration in Electrophoresis)
Pre-albumin Albumin a1-globulin: \_\_\_\_\_\_\_\_\_\_\_\_ a2-globulin: \_\_\_\_\_\_\_\_\_\_\_\_ b-globulin: \_\_\_\_\_\_\_\_\_\_\_\_\_ y-globulin: \_\_\_\_\_\_\_\_\_\_\_\_\_
Pre-albumin
Albumin
a1-globulin: a1-antitrypsin, a1-acid glycoprotein, a-fetoprotein, Group-specific component globulin, a1-antichymotrypsin
a2-globulin: a2-macroglobulin, ceruloplasmin, haptoglobin
b-globulin: Transferrin, Hemopexin, b2-microglobulin, complement, Fibrinogen, Lipoproteins
y-globulin: Immunoglobulins, CRP
Prealbumin is also known as __________
Transthyretin
Used in Malnutrition Detection
Prealbumin
Albumin is a ______ acute phase reactant and a _______ transport protein.
Negative Acute Phase Reactant
General Transport Medium
Prognostic Marker for Cystic Fibrosis
Albumin
Presence of 2 bands in the albumin region
Bisalbuminemia
Major inhibitor of protease activity (protease neutrophil elastase)
a1-antitrypsin
Deficiency of a1-antitrypsin causes damage in alveoli that results to ___________________
Emphysema or Emphysematous pulmonary Disease
Most Abundant in Fetal Serum
AFP
AFP can be detectable in maternal blood up to ____ or ____ week.
7th or 8th week
Increased AFP in maternal blood can cause ________________ and _________________
Spina Bifida
Neural Tube Defects
Tumor Marker for Hepatic (HCC) and Gonadal
Alpha fetoprotein
Exhibits affinity with Vitamin D and actin or Vitamin D binding protein
Group specific component Globulin
a1 antichymotrypsin binds and inactivates __________________ and is associated with ____________.
Inactivates PSA and is associated with Alzheimer’s disease.
Largest non-immunoglobulin in plasma
a2 macroglobulin
a2 macroglobulin is increased 10x in _______________
Nephrosis/Nephrotic Syndrome
Copper-binding protein and a marker for Wilson’s disease
Ceruloplasmin
Decreased ceruloplasmin is seen in _______________, and _____________
Wilson’s Disease
Menke’s kinky-hair
Condition with deposition of copper in skin, liver, brain and cornea (Kayser Fisher rings)
Wilsons Disease
Binds Free Hemoglobin in its alpha chain
Haptoglobin
Light chain component of HLA
B2 microglobulin
Transports Iron and prevent Iron Loss
Transferrin/Siderophilin
Binds Heme released by degradation of Hb
Hemopexin